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Year Number of Results
1961 2
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1975 7
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1978 6
1979 3
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1982 6
1983 1
1984 2
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1989 1
1991 1
1993 1
1997 1
1998 4
2000 1
2001 8
2002 31
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2004 55
2005 67
2006 84
2007 117
2008 131
2009 128
2010 158
2011 170
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2,767 results

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Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells.
Sun H, Wang H, Wang X, Aoki Y, Wang X, Yang Y, Cheng X, Wang Z, Wang X. Sun H, et al. Theranostics. 2020 May 25;10(15):6928-6945. doi: 10.7150/thno.43811. eCollection 2020. Theranostics. 2020. PMID: 32550913 Free PMC article.
Furthermore, Aurora-A promoted chemoresistance through suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells. ...Conclusions: Aurora-A regulates cell senescence and glucose metabolism to induce cisplat …
Furthermore, Aurora-A promoted chemoresistance through suppression of cell senescence and induction of glucose metabolism in o …
CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2.
Holder J, Miles JA, Batchelor M, Popple H, Walko M, Yeung W, Kannan N, Wilson AJ, Bayliss R, Gergely F. Holder J, et al. EMBO J. 2024 Nov;43(22):5381-5420. doi: 10.1038/s44318-024-00240-z. Epub 2024 Sep 26. EMBO J. 2024. PMID: 39327527 Free PMC article.
Deleting the Aurora-A-binding interface in CEP192 prevents centrosomal accumulation of Aurora-A, curtails its activation-loop phosphorylation, and reduces spindle-bound TPX2:Aurora-A complexes, resulting in error-prone mitosis. Thus, by s …
Deleting the Aurora-A-binding interface in CEP192 prevents centrosomal accumulation of Aurora-A, curtails its ac …
The role of aurora A and polo-like kinases in high-risk lymphomas.
Murga-Zamalloa C, Inamdar KV, Wilcox RA. Murga-Zamalloa C, et al. Blood Adv. 2019 Jun 11;3(11):1778-1787. doi: 10.1182/bloodadvances.2019000232. Blood Adv. 2019. PMID: 31186254 Free PMC article. Review.
Recurrent genetic and molecular alterations, including c-myc expression and aurora A kinase (AAK) and polo-like kinase-1 (PLK1) activation, promote cell proliferation and contribute to the highly aggressive natural history associated with these lymphoproliferative d …
Recurrent genetic and molecular alterations, including c-myc expression and aurora A kinase (AAK) and polo-like kinase-1 (PLK1 …
Role of Aurora-A in Ovarian Cancer: A Meta-Analysis.
He Y, Jiang W, Qian X, Liu F, Zhang Q, You C. He Y, et al. Oncol Res Treat. 2015;38(9):442-7. doi: 10.1159/000439194. Epub 2015 Aug 18. Oncol Res Treat. 2015. PMID: 26406304 Review.
Therefore, the aim of this study was to evaluate the prognostic significance of Aurora-A in ovarian cancer by performing a meta-analysis. METHODS: PubMed, Cochrane library, Web of Science, Embase, Medline and Chinese BioMed Database (CBM) databases were searched sys …
Therefore, the aim of this study was to evaluate the prognostic significance of Aurora-A in ovarian cancer by performing a met …
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer.
Naso FD, Boi D, Ascanelli C, Pamfil G, Lindon C, Paiardini A, Guarguaglini G. Naso FD, et al. Oncogene. 2021 Jun;40(23):3917-3928. doi: 10.1038/s41388-021-01766-w. Epub 2021 May 13. Oncogene. 2021. PMID: 33981003 Free PMC article. Review.
The Aurora-A kinase regulates cell division, by controlling centrosome biology and spindle assembly. ...We review existing data in the literature and databases, examining potential links between Aurora-A stabilisation and localisation, and discuss them …
The Aurora-A kinase regulates cell division, by controlling centrosome biology and spindle assembly. ...We review existing dat …
A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis.
Lai CH, Chen RY, Hsieh HP, Tsai SJ, Chang KC, Yen CJ, Huang YC, Liu YW, Lee JC, Lai YC, Hung LY, Lin BW. Lai CH, et al. Cancer Lett. 2020 Mar 1;472:97-107. doi: 10.1016/j.canlet.2019.12.031. Epub 2019 Dec 23. Cancer Lett. 2020. PMID: 31875524
Many Aurora-A inhibitors have been developed for cancer therapy; however, the specificity and safety of Aurora-A inhibitors remain uncertain. ...Interestingly, we found that the exon 2-containing Aurora-A mRNA isoforms are predominantly e …
Many Aurora-A inhibitors have been developed for cancer therapy; however, the specificity and safety of Aurora-A
Aurora A kinase (AURKA) in normal and pathological cell division.
Nikonova AS, Astsaturov I, Serebriiskii IG, Dunbrack RL Jr, Golemis EA. Nikonova AS, et al. Cell Mol Life Sci. 2013 Feb;70(4):661-87. doi: 10.1007/s00018-012-1073-7. Epub 2012 Aug 3. Cell Mol Life Sci. 2013. PMID: 22864622 Free PMC article. Review.
More recently, identification of additional, non-mitotic functions and means of activation of Aurora A during interphase neurite elongation and ciliary resorption have significantly expanded our understanding of its function, and may offer insights into the clinical …
More recently, identification of additional, non-mitotic functions and means of activation of Aurora A during interphase neuri …
OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.
Kim HJ, Kim J. Kim HJ, et al. Int J Mol Sci. 2021 Feb 16;22(4):1936. doi: 10.3390/ijms22041936. Int J Mol Sci. 2021. PMID: 33669244 Free PMC article.
Through pull-down assays with the human DUB library, we identified OTUD6A as an Aurora-A-specific DUB. OTUD6A interacts with Aurora-A through OTU and kinase domains, respectively, and deubiquitinates Aurora-A. Notably, OTUD6A promotes the …
Through pull-down assays with the human DUB library, we identified OTUD6A as an Aurora-A-specific DUB. OTUD6A interacts with …
Covalent Aurora A regulation by the metabolic integrator coenzyme A.
Tsuchiya Y, Byrne DP, Burgess SG, Bormann J, Baković J, Huang Y, Zhyvoloup A, Yu BYK, Peak-Chew S, Tran T, Bellany F, Tabor AB, Chan AE, Guruprasad L, Garifulin O, Filonenko V, Vonderach M, Ferries S, Eyers CE, Carroll J, Skehel M, Bayliss R, Eyers PA, Gout I. Tsuchiya Y, et al. Redox Biol. 2020 Jan;28:101318. doi: 10.1016/j.redox.2019.101318. Epub 2019 Sep 5. Redox Biol. 2020. PMID: 31546169 Free PMC article.
Aurora A kinase is a master mitotic regulator whose functions are controlled by several regulatory interactions and post-translational modifications. It is frequently dysregulated in cancer, making Aurora A inhibition a very attractive antitumor target
Aurora A kinase is a master mitotic regulator whose functions are controlled by several regulatory interactions and post-trans
2,767 results