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. 2003 Nov 20;554(3):410-6.
doi: 10.1016/s0014-5793(03)01212-2.

Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue

Emma E Tarttelin  1 , James Bellingham, Mark W Hankins, Russell G Foster, Robert J Lucas
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Free article

Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue

Emma E Tarttelin et al. FEBS Lett. .
Free article

Abstract

We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord.

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