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Sub-lingual administration of a polyvalent mechanical bacterial lysate (PMBL) in patients with moderate, severe, or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD spirometric classification: A multicentre, double-blind, randomised, controlled, phase IV study (AIACE study: Advanced Immunological Approach in COPD Exacerbation).
Braido F, Melioli G, Cazzola M, Fabbri L, Blasi F, Moretta L, Canonica GW; AIACE Study Group. Braido F, et al. Pulm Pharmacol Ther. 2015 Aug;33:75-80. doi: 10.1016/j.pupt.2015.03.006. Epub 2015 May 5. Pulm Pharmacol Ther. 2015. PMID: 25951945 Clinical Trial.