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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1831 1
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1853 1
1856 1
1860 1
1876 2
1886 2
1887 4
1888 2
1889 3
1890 3
1891 2
1892 4
1893 2
1894 3
1895 2
1896 2
1897 4
1898 3
1899 8
1900 3
1902 7
1905 1
1908 2
1909 4
1910 5
1911 1
1912 4
1913 12
1914 10
1915 11
1916 7
1917 7
1918 2
1919 8
1920 12
1921 10
1922 3
1923 2
1924 3
1925 4
1926 1
1927 1
1928 2
1929 1
1930 1
1931 5
1932 1
1934 2
1935 7
1936 3
1937 2
1938 2
1940 1
1943 1
1944 1
1945 7
1946 7
1947 11
1948 12
1949 12
1950 6
1951 10
1952 6
1953 10
1954 12
1955 9
1956 8
1957 3
1958 14
1959 15
1960 12
1961 13
1962 15
1963 23
1964 21
1965 27
1966 42
1967 50
1968 52
1969 54
1970 74
1971 71
1972 68
1973 71
1974 74
1975 142
1976 150
1977 198
1978 224
1979 244
1980 242
1981 297
1982 403
1983 459
1984 568
1985 599
1986 693
1987 761
1988 866
1989 978
1990 1257
1991 1362
1992 1604
1993 1813
1994 2037
1995 2330
1996 2921
1997 3226
1998 4049
1999 5385
2000 8930
2001 12228
2002 13761
2003 17387
2004 18763
2005 20921
2006 20713
2007 20265
2008 20009
2009 18869
2010 20330
2011 20770
2012 22034
2013 24992
2014 30243
2015 32652
2016 33392
2017 32441
2018 32329
2019 32029
2020 34584
2021 36638
2022 35600
2023 32530
2024 33116
2025 32854
2026 7554

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625,556 results

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Page 1
The Biology of F-box Proteins: The SCF Family of E3 Ubiquitin Ligases.
Nguyen KM, Busino L. Nguyen KM, et al. Adv Exp Med Biol. 2020;1217:111-122. doi: 10.1007/978-981-15-1025-0_8. Adv Exp Med Biol. 2020. PMID: 31898225 Review.
F-box proteins function as substrate adaptors for the S-phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes, which mediate the proteasomal degradation of a diverse range of regulatory proteins. 20 years since the F …
F-box proteins function as substrate adaptors for the S-phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein …
Role for the F-box proteins in heart diseases.
Liu S, Yang Y, Hou X, Zhou N, Zhang B, Li W. Liu S, et al. Pharmacol Res. 2024 Dec;210:107514. doi: 10.1016/j.phrs.2024.107514. Epub 2024 Nov 20. Pharmacol Res. 2024. PMID: 39577754 Free article. Review.
The maintenance of cardiac homeostasis necessitates proper protein turnover, which is regulated by the ubiquitin-proteasome system. F-box proteins are one type of E3 ubiquitin ligases, and accumulating evidence suggests that dysregulation of FBPs exacerbates heart diseases …
The maintenance of cardiac homeostasis necessitates proper protein turnover, which is regulated by the ubiquitin-proteasome system. F-box …
F-box only protein 9 and its role in cancer.
Hussain S, Dong J, Ma X, Li J, Chen S, Clement A, Liu H. Hussain S, et al. Mol Biol Rep. 2022 Feb;49(2):1537-1544. doi: 10.1007/s11033-021-07057-7. Epub 2022 Jan 13. Mol Biol Rep. 2022. PMID: 35025031 Review.
The F-box proteins (FBP), substrate recognition subunit of the SCF (Skp1-Cullin1-F-box protein complex) E3 ligase, play important roles in the ubiquitylation and subsequent degradation of the target proteins from several cellular processes. ...Targeting F-box …
The F-box proteins (FBP), substrate recognition subunit of the SCF (Skp1-Cullin1-F-box protein complex) E3 ligase, play import …
Role of DEAD/DEAH-box helicases in immunity, infection and cancers.
Devasahayam Arokia Balaya R, Kanekar S, Kumar S, Kandasamy RK. Devasahayam Arokia Balaya R, et al. Cell Commun Signal. 2025 Jun 19;23(1):292. doi: 10.1186/s12964-025-02225-9. Cell Commun Signal. 2025. PMID: 40537811 Free PMC article. Review.
These motifs delineate two subfamilies: DEAD-box (DDX) and DEAH-box (DHX). DEAD-box proteins predominantly facilitate localized non-processive RNA duplex destabilization, whereas DEAH-box helicases mediate processive RNA translocation and unwinding. .. …
These motifs delineate two subfamilies: DEAD-box (DDX) and DEAH-box (DHX). DEAD-box proteins predominantly facilitate l …
Inhibitors Targeting the F-BOX Proteins.
Naseem Y, Zhang C, Zhou X, Dong J, Xie J, Zhang H, Agboyibor C, Bi Y, Liu H. Naseem Y, et al. Cell Biochem Biophys. 2023 Dec;81(4):577-597. doi: 10.1007/s12013-023-01160-1. Epub 2023 Aug 25. Cell Biochem Biophys. 2023. PMID: 37624574 Review.
Any significant mutation in F-box protein-mediated proteolysis can cause human malformations. The various cellular processes F-box proteins involved include cell proliferation, apoptosis, invasion, angiogenesis, and metastasis. To target F-box proteins and th …
Any significant mutation in F-box protein-mediated proteolysis can cause human malformations. The various cellular processes F-box …
DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense.
Taschuk F, Cherry S. Taschuk F, et al. Viruses. 2020 Feb 5;12(2):181. doi: 10.3390/v12020181. Viruses. 2020. PMID: 32033386 Free PMC article. Review.
DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family have roles throughout cellular RNA metabolism from biogenesis to decay. ...
DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to the broader group of cellular DExD/H helicases …
DExD/H-box helicases: multifunctional regulators in antiviral innate immunity.
Su C, Tang YD, Zheng C. Su C, et al. Cell Mol Life Sci. 2021 Dec 15;79(1):2. doi: 10.1007/s00018-021-04072-6. Cell Mol Life Sci. 2021. PMID: 34910251 Free PMC article. Review.
DExD/H-box helicases play critical roles in multiple cellular processes, including transcription, cellular RNA metabolism, translation, and infections. ...Here we summarize the complex regulatory roles of DExD/H-box helicases in antiviral innate immunity. A better u …
DExD/H-box helicases play critical roles in multiple cellular processes, including transcription, cellular RNA metabolism, translatio …
Context-dependent T-BOX transcription factor family: from biology to targeted therapy.
Li S, Luo X, Sun M, Wang Y, Zhang Z, Jiang J, Hu D, Zhang J, Wu Z, Wang Y, Huang W, Xia L. Li S, et al. Cell Commun Signal. 2024 Jul 4;22(1):350. doi: 10.1186/s12964-024-01719-2. Cell Commun Signal. 2024. PMID: 38965548 Free PMC article. Review.
T-BOX factors belong to an evolutionarily conserved family of transcription factors. T-BOX factors not only play key roles in growth and development but are also involved in immunity, cancer initiation, and progression. ...Understanding the multiple roles of context …
T-BOX factors belong to an evolutionarily conserved family of transcription factors. T-BOX factors not only play key roles in …
Role of F-box proteins in human upper gastrointestinal tumors.
Zhang C, Pan G, Qin JJ. Zhang C, et al. Biochim Biophys Acta Rev Cancer. 2024 Jan;1879(1):189035. doi: 10.1016/j.bbcan.2023.189035. Epub 2023 Dec 2. Biochim Biophys Acta Rev Cancer. 2024. PMID: 38049014 Review.
Currently, there is an increasing focus on studying the role of F-box proteins in cancer. In this review, we present a comprehensive overview of the significant contributions of F-box proteins to the development of upper gastrointestinal tumors, highlighting their d …
Currently, there is an increasing focus on studying the role of F-box proteins in cancer. In this review, we present a comprehensive …
F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects.
Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X, Piao HL, Liu H. Tekcham DS, et al. Theranostics. 2020 Mar 4;10(9):4150-4167. doi: 10.7150/thno.42735. eCollection 2020. Theranostics. 2020. PMID: 32226545 Free PMC article. Review.
According to the specific domains, F-box proteins are further classified into three sub-families: 1) F-box with leucine rich amino acid repeats (FBXL); 2) F-box with WD 40 amino acid repeats (FBXW); 3) F-box only with uncharacterized domains (FBXO). He …
According to the specific domains, F-box proteins are further classified into three sub-families: 1) F-box with leucine rich a …
625,556 results
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