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Page 1
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue.
Andrews R, Fu B, Toomey CE, Breiter JC, Lachica J, Beckwith JS, Tian R, Brock EE, Needham LM, Chant GJ, Loiseau C, Deconfin A, Baspin K, Popovic R, Evans J, Goh Y, Kurt B, Senicar L, Edmonds M, Bartels T, Bengoa-Vergniory N, Magill PJ, Jaunmuktane Z, Freeman OJ, Taylor BJM, Hardy J, Lashley T, Ryten M, Vendruscolo M, Wood NW, Weiss LE, Gandhi S, Lee SF. Andrews R, et al. Among authors: breiter jc. Nat Biomed Eng. 2025 Oct 1. doi: 10.1038/s41551-025-01496-4. Online ahead of print. Nat Biomed Eng. 2025. PMID: 41034512
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.
Fu B, Brock EE, Andrews R, Breiter JC, Tian R, Toomey CE, Lachica J, Lashley T, Ryten M, Wood NW, Vendruscolo M, Gandhi S, Weiss LE, Beckwith JS, Lee SF. Fu B, et al. Among authors: breiter jc. J Phys Chem B. 2024 Apr 18;128(15):3585-3597. doi: 10.1021/acs.jpcb.4c00174. Epub 2024 Apr 9. J Phys Chem B. 2024. PMID: 38593280 Free PMC article.
The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer's disease mouse model.
de Veij Mestdagh CF, Koopmans F, Breiter JC, Timmerman JA, Vogelaar PC, Krenning G, Mansvelder HD, Smit AB, Henning RH, van Kesteren RE. de Veij Mestdagh CF, et al. Among authors: breiter jc. Alzheimers Res Ther. 2022 Dec 9;14(1):183. doi: 10.1186/s13195-022-01127-z. Alzheimers Res Ther. 2022. PMID: 36482297 Free PMC article.
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.
Cotton MW, Venkatesan S, Beckwith JS, Böken D, Xu CK, Fertan E, Breiter JC, Berkowicz LE, Salazar LS, Von Schulze A, Andrzejewska EA, Brock EE, Han HL, Schneider MM, Sahtoe DD, Baker D, Rowe JB, Goriely A, McEwan WA, Knowles TPJ, Lee SF, Halfmann R, Klenerman D, Meisl G. Cotton MW, et al. Among authors: breiter jc. bioRxiv [Preprint]. 2025 Oct 30:2025.09.08.674880. doi: 10.1101/2025.09.08.674880. bioRxiv. 2025. PMID: 41040193 Free PMC article. Preprint.
22 results