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2013 1
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28 results

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Page 1
ATR promotes mTORC1 activity via de novo cholesterol synthesis.
Tangudu NK, Grumet AN, Fang R, Buj R, Cole AR, Uboveja A, Amalric A, Yang B, Huang Z, Happe C, Sun M, Gelhaus SL, MacDonald ML, Hempel N, Snyder NW, Kedziora KM, Valvezan AJ, Aird KM. Tangudu NK, et al. Among authors: buj r. EMBO Rep. 2025 Jul;26(14):3574-3593. doi: 10.1038/s44319-025-00451-3. Epub 2025 Jun 13. EMBO Rep. 2025. PMID: 40514450 Free PMC article.
De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression.
Tangudu NK, Buj R, Wang H, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Yang B, Chatoff A, Crispim CV, Sajjakulnukit P, Lyons MA, Cooper K, Hempel N, Lyssiotis CA, Chandran UR, Snyder NW, Aird KM. Tangudu NK, et al. Among authors: buj r. Cancer Res Commun. 2024 May 2;4(5):1174-1188. doi: 10.1158/2767-9764.CRC-23-0450. Cancer Res Commun. 2024. PMID: 38626341 Free PMC article.
The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming.
Cole AR, Buj R, Uboveja A, Levasseur E, Wang H, Kedziora KM, Chatoff A, Huacachino AA, Marcinkiewicz MM, Amalric A, Yang B, Tangudu NK, Danielson J, Elwah A, White S, Li D, Wallace CT, Lazure F, Elishaev E, Borho L, Jazwinska DE, Laird MS, Atiya H, Bitler BG, Dangaj D, Coffman LG, Tseng G, Oesterreich S, Gomes AP, Gurkar AU, Schopfer FJ, Modugno F, Watkins SC, Zervantonakis IK, Stallaert W, Hempel N, Snyder NW, Aird KM. Cole AR, et al. Among authors: buj r. bioRxiv [Preprint]. 2025 Aug 12:2023.12.02.569652. doi: 10.1101/2023.12.02.569652. bioRxiv. 2025. PMID: 40832218 Free PMC article. Preprint.
p16: cycling off the beaten path.
Buj R, Aird KM. Buj R, et al. Mol Cell Oncol. 2019 Oct 15;6(6):e1677140. doi: 10.1080/23723556.2019.1677140. eCollection 2019. Mol Cell Oncol. 2019. PMID: 31692916 Free PMC article.
Zinc availability in the tumor microenvironment dictates anti-PD1 response in CDKN2A Low tumors via increased macrophage phagocytosis.
Buj R, Cole AR, Danielson J, Xu J, Hurd D, Kishore A, Kedziora KM, Chen J, Yang B, Barras D, Uboveja A, Amalric A, Apiz Saab JJ, Wickramasinghe J, Tangudu NK, Levasseur E, Wang H, Minasyan A, Dadey RE, Sharrow AC, Kunning S, Vendetti FP, Rivadeneira DB, Bakkenist CJ, Bruno TC, Delgoffe GM, Hempel N, Snyder NW, Bao R, Soloff AC, Kirk-Wood JM, Dangaj Laniti D, Kossenkov AV, Muir A, Das J, Davar D, Mesaros C, Aird KM. Buj R, et al. bioRxiv [Preprint]. 2025 Aug 5:2025.02.08.637227. doi: 10.1101/2025.02.08.637227. bioRxiv. 2025. PMID: 39975044 Free PMC article. Preprint.
ATM inhibition drives metabolic adaptation via induction of macropinocytosis.
Huang Z, Chen CW, Buj R, Tangudu NK, Fang RS, Leon KE, Dahl ES, Varner EL, von Krusenstiern E, Cole AR, Snyder NW, Aird KM. Huang Z, et al. Among authors: buj r. J Cell Biol. 2023 Jan 2;222(1):e202007026. doi: 10.1083/jcb.202007026. Epub 2022 Nov 18. J Cell Biol. 2023. PMID: 36399181 Free PMC article.
28 results