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41 results

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Page 1
CT1812 biomarker signature from a meta-analysis of CSF proteomic findings from two Phase 2 clinical trials in Alzheimer's disease.
Lizama BN, Williams C, North HA, Pandey K, Duong D, Di Caro V, Mecca AP, Blennow K, Zetterberg H, Levey AI, Grundman M, van Dyck CH, Caggiano AO, Seyfried NT, Hamby ME. Lizama BN, et al. Among authors: caggiano ao. Alzheimers Dement. 2024 Oct;20(10):6860-6880. doi: 10.1002/alz.14152. Epub 2024 Aug 21. Alzheimers Dement. 2024. PMID: 39166791 Free PMC article. Clinical Trial.
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease.
Colom-Cadena M, Toombs J, Simzer E, Holt K, McGeachan R, Tulloch J, Jackson RJ, Catterson JH, Spires-Jones MP, Rose J, Waybright L, Caggiano AO, King D, Gobbo F, Davies C, Hooley M, Dunnett S, Tempelaar R, Meftah S, Tzioras M, Hamby ME, Izzo NJ, Catalano SM, Durrant CS, Smith C, Dando O, Spires-Jones TL. Colom-Cadena M, et al. Among authors: caggiano ao. Acta Neuropathol. 2024 Feb 6;147(1):32. doi: 10.1007/s00401-023-02679-6. Acta Neuropathol. 2024. PMID: 38319380 Free PMC article.
An interim exploratory proteomics biomarker analysis of a phase 2 clinical trial to assess the impact of CT1812 in Alzheimer's disease.
Lizama BN, North HA, Pandey K, Williams C, Duong D, Cho E, Di Caro V, Ping L, Blennow K, Zetterberg H, Lah J, Levey AI, Grundman M, Caggiano AO, Seyfried NT, Hamby ME. Lizama BN, et al. Among authors: caggiano ao. Neurobiol Dis. 2024 Sep;199:106575. doi: 10.1016/j.nbd.2024.106575. Epub 2024 Jun 22. Neurobiol Dis. 2024. PMID: 38914170 Free article. Clinical Trial.
Identification of cerebrospinal fluid pharmacodynamic biomarkers and molecular correlates of brain activity in a Phase 2 clinical trial of the Alzheimer's disease drug candidate CT1812.
Di Caro V, Cho E, North HA, Caldwell J, Pandey K, Duong D, Grundman M, de Haan W, Vijverberg EG, Teunissen CE, Caggiano AO, Seyfried NT, Hamby ME. Di Caro V, et al. Among authors: caggiano ao. Alzheimers Dement (N Y). 2025 Jun 19;11(2):e70119. doi: 10.1002/trc2.70119. eCollection 2025 Apr-Jun. Alzheimers Dement (N Y). 2025. PMID: 40547328 Free PMC article.
Sigma-2 receptor modulator CT1812 alters key pathways and rescues retinal pigment epithelium (RPE) functional deficits associated with dry age-related macular degeneration (AMD).
Lizama BN, Keeling E, Cho E, Malagise EM, Knezovich N, Waybright L, Watto E, Look G, Di Caro V, Caggiano AO, Ratnayaka JA, Hamby ME. Lizama BN, et al. Among authors: caggiano ao. Sci Rep. 2025 Feb 10;15(1):4256. doi: 10.1038/s41598-025-87921-9. Sci Rep. 2025. PMID: 39929889 Free PMC article.
A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1β3) in Patients With Systolic Dysfunction and Heart Failure.
Lenihan DJ, Anderson SA, Lenneman CG, Brittain E, Muldowney JAS 3rd, Mendes L, Zhao PZ, Iaci J, Frohwein S, Zolty R, Eisen A, Sawyer DB, Caggiano AO. Lenihan DJ, et al. Among authors: caggiano ao. JACC Basic Transl Sci. 2016 Dec 26;1(7):576-586. doi: 10.1016/j.jacbts.2016.09.005. eCollection 2016 Dec. JACC Basic Transl Sci. 2016. PMID: 30167542 Free PMC article. Review.
Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury.
Rosenzweig ES, Salegio EA, Liang JJ, Weber JL, Weinholtz CA, Brock JH, Moseanko R, Hawbecker S, Pender R, Cruzen CL, Iaci JF, Caggiano AO, Blight AR, Haenzi B, Huie JR, Havton LA, Nout-Lomas YS, Fawcett JW, Ferguson AR, Beattie MS, Bresnahan JC, Tuszynski MH. Rosenzweig ES, et al. Among authors: caggiano ao. Nat Neurosci. 2019 Aug;22(8):1269-1275. doi: 10.1038/s41593-019-0424-1. Epub 2019 Jun 24. Nat Neurosci. 2019. PMID: 31235933 Free PMC article.
41 results