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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrén E. Casarotto PC, et al. Among authors: cannarozzo c. Cell. 2021 Mar 4;184(5):1299-1313.e19. doi: 10.1016/j.cell.2021.01.034. Epub 2021 Feb 18. Cell. 2021. PMID: 33606976 Free PMC article.
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.
Moliner R, Girych M, Brunello CA, Kovaleva V, Biojone C, Enkavi G, Antenucci L, Kot EF, Goncharuk SA, Kaurinkoski K, Kuutti M, Fred SM, Elsilä LV, Sakson S, Cannarozzo C, Diniz CRAF, Seiffert N, Rubiolo A, Haapaniemi H, Meshi E, Nagaeva E, Öhman T, Róg T, Kankuri E, Vilar M, Varjosalo M, Korpi ER, Permi P, Mineev KS, Saarma M, Vattulainen I, Casarotto PC, Castrén E. Moliner R, et al. Among authors: cannarozzo c. Nat Neurosci. 2023 Jun;26(6):1032-1041. doi: 10.1038/s41593-023-01316-5. Epub 2023 Jun 5. Nat Neurosci. 2023. PMID: 37280397 Free PMC article.
Fluoxetine and Ketamine Enhance Extinction Memory and Brain Plasticity by Triggering the p75 Neurotrophin Receptor Proteolytic Pathway.
Diniz CRAF, Crestani AP, Casarotto PC, Biojone C, Cannarozzo C, Winkel F, Prozorov MA, Kot EF, Goncharuk SA, Benette Marques D, Rakauskas Zacharias L, Autio H, Sahu MP, Borges-Assis AB, Leite JP, Mineev KS, Castrén E, Resstel LBM. Diniz CRAF, et al. Among authors: cannarozzo c. Biol Psychiatry. 2025 Feb 1;97(3):248-260. doi: 10.1016/j.biopsych.2024.06.021. Epub 2024 Jun 28. Biol Psychiatry. 2025. PMID: 38945387 Free article.
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