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Neutrophils drive vascular occlusion, tumour necrosis and metastasis.
Adrover JM, Han X, Sun L, Fujii T, Sivetz N, Daßler-Plenker J, Evans C, Peters J, He XY, Cannon CD, Ho WJ, Raptis G, Powers RS, Egeblad M. Adrover JM, et al. Among authors: cannon cd. Nature. 2025 Sep;645(8080):484-495. doi: 10.1038/s41586-025-09278-3. Epub 2025 Jul 16. Nature. 2025. PMID: 40670787 Free PMC article.
3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure.
Kiemen AL, Almagro-Pérez C, Matos V, Forjaz A, Braxton AM, Dequiedt L, Parksong J, Cannon CD, Yuan X, Shin SM, Babu JM, Thompson ED, Cornish TC, Ho WJ, Wood LD, Wu PH, Barrutia AM, Hruban RH, Wirtz D. Kiemen AL, et al. Among authors: cannon cd. bioRxiv [Preprint]. 2024 Aug 6:2024.08.03.606493. doi: 10.1101/2024.08.03.606493. bioRxiv. 2024. PMID: 39149369 Free PMC article. Preprint.
A phase 2 trial of CXCR4 antagonism and PD1 inhibition in metastatic pancreatic adenocarcinoma reveals recruitment of T cells but also immunosuppressive macrophages.
Bever KM, Shin SM, Durham JN, Qi H, Hernandez A, Coyne EM, Gross NE, Charmsaz S, Suresh Babu J, Vargas Carvajal DC, Verma R, Sun Y, Zhang Z, Yuan X, Cannon CD, Hughes SN, Mitchell S, Figlewski M, Leatherman JM, Wang H, Anders RA, Jaffee EM, Le DT, Ho WJ. Bever KM, et al. Among authors: cannon cd. Oncoimmunology. 2025 Dec;14(1):2543614. doi: 10.1080/2162402X.2025.2543614. Epub 2025 Aug 15. Oncoimmunology. 2025. PMID: 40815609 Free PMC article. Clinical Trial.