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Accelerating high-concentration monoclonal antibody development with large-scale viscosity data and ensemble deep learning.
Kalejaye LA, Chu JM, Wu IE, Amofah B, Lee A, Hutchinson M, Chakiath C, Dippel A, Kaplan G, Damschroder M, Stanev V, Pouryahya M, Boroumand M, Caldwell J, Hinton A, Kreitz M, Shah M, Gallegos A, Mody N, Lai PK. Kalejaye LA, et al. Among authors: chakiath c. MAbs. 2025 Dec;17(1):2483944. doi: 10.1080/19420862.2025.2483944. Epub 2025 Apr 1. MAbs. 2025. PMID: 40170162 Free PMC article.
Gateway cloning for protein expression.
Esposito D, Garvey LA, Chakiath CS. Esposito D, et al. Among authors: chakiath cs. Methods Mol Biol. 2009;498:31-54. doi: 10.1007/978-1-59745-196-3_3. Methods Mol Biol. 2009. PMID: 18988017
Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine.
Seder RA, Chang LJ, Enama ME, Zephir KL, Sarwar UN, Gordon IJ, Holman LA, James ER, Billingsley PF, Gunasekera A, Richman A, Chakravarty S, Manoj A, Velmurugan S, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, Plummer SH, Hendel CS, Novik L, Costner PJ, Mendoza FH, Saunders JG, Nason MC, Richardson JH, Murphy J, Davidson SA, Richie TL, Sedegah M, Sutamihardja A, Fahle GA, Lyke KE, Laurens MB, Roederer M, Tewari K, Epstein JE, Sim BK, Ledgerwood JE, Graham BS, Hoffman SL; VRC 312 Study Team. Seder RA, et al. Science. 2013 Sep 20;341(6152):1359-65. doi: 10.1126/science.1241800. Epub 2013 Aug 8. Science. 2013. PMID: 23929949 Clinical Trial.
A Reactive Antibody Platform for One-Step Production of Antibody-Drug Conjugates through a Diels-Alder Reaction with Maleimide.
St Amant AH, Huang F, Lin J, Lemen D, Chakiath C, Mao S, Fazenbaker C, Zhong H, Harper J, Xu W, Patel N, Adams L, Vijayakrishnan B, Howard PW, Marelli M, Wu H, Gao C, Read de Alaniz J, Christie RJ. St Amant AH, et al. Among authors: chakiath c. Bioconjug Chem. 2019 Sep 18;30(9):2340-2348. doi: 10.1021/acs.bioconjchem.9b00436. Epub 2019 Aug 19. Bioconjug Chem. 2019. PMID: 31380623