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. 2020 Nov 10;10(11):e042398.
doi: 10.1136/bmjopen-2020-042398.

Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study

Eva Jiménez  1 , Mario Fontán-Vela #  2 , Jorge Valencia  3 , Ines Fernandez-Jimenez  2 , Elena Alba Álvaro-Alonso  4 , Elsa Izquierdo-García  4 , Andrea Lazaro Cebas  4 , Elisa Gallego Ruiz-Elvira  2 , Jesús Troya  3 , Ana Josefa Tebar-Martinez  2 , Belén Garcia-Marina  5 , Gabriela Peña-Lillo  5 , Ane Abad-Motos  6 , Laura Macaya  7 , Pablo Ryan #  3 , Mario Pérez-Butragueño  8 ; COVID@HUIL Working Group; COVID@HUIL Working Group
Collaborators, Affiliations

Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study

Eva Jiménez et al. BMJ Open. .

Abstract

Objectives: To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital.

Design and setting: Retrospective case series of sequentially hospitalised patients with confirmed SARS-CoV-2, at Infanta Leonor University Hospital (ILUH) in Madrid, Spain.

Participants: All patients attended at ILUH testing positive to reverse transcriptase-PCR on nasopharyngeal swabs and diagnosed with COVID-19 between 1 March 2020 and 28 May 2020.

Results: A total of 1549 COVID-19 cases were included (median age 69 years (IQR 55.0-81.0), 57.5% men). 78.2% had at least one underlying comorbidity, the most frequent was hypertension (55.8%). Most frequent symptoms at presentation were fever (75.3%), cough (65.7%) and dyspnoea (58.1%). 81 (5.8%) patients were admitted to the intensive care unit (ICU) (median age 62 years (IQR 51-71); 74.1% men; median length of stay 9 days (IQR 5-19)) 82.7% of them needed invasive ventilation support. 1393 patients had an outcome at the end of the study period (case fatality ratio: 21.2% (296/1393)). The independent factors associated with fatality (OR; 95% CI): age (1.07; 1.06 to 1.09), male sex (2.86; 1.85 to 4.50), neurological disease (1.93; 1.19 to 3.13), chronic kidney disease (2.83; 1.40 to 5.71) and neoplasia (4.29; 2.40 to 7.67). The percentage of hospital beds occupied with COVID-19 almost doubled (702/361), with the number of patients in ICU quadrupling its capacity (32/8). Median length of stay was 9 days (IQR 6-14).

Conclusions: This study provides clinical characteristics, complications and outcomes of patients with COVID-19 admitted to a European secondary hospital. Fatal outcomes were similar to those reported by hospitals with a higher level of complexity.

Keywords: COVID-19; epidemiology; infectious diseases; public health.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Epidemic curve of COVID-19 confirmed cases seen at ILUH. ILUH, Infanta Leonor University Hospital.
Figure 2
Figure 2
Population flow chart. ICU, intensive care unit; ILUH, Infanta Leonor University Hospital.
See this image and copyright information in PMC

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