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213 results

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Page 1
Showing results for compels cc
Search for Compes CC instead (2 results)
Potential treatment targets for migraine: emerging options and future prospects.
Chiang CC, Porreca F, Robertson CE, Dodick DW. Chiang CC, et al. Lancet Neurol. 2024 Mar;23(3):313-324. doi: 10.1016/S1474-4422(24)00003-6. Lancet Neurol. 2024. PMID: 38365382 Review.
Exploring additional targets that have compelling evidence for their involvement in modulating migraine pathways is therefore imperative. ...
Exploring additional targets that have compelling evidence for their involvement in modulating migraine pathways is therefore imperat …
Lead-in calorie restriction enhances the weight-lowering efficacy of incretin hormone-based pharmacotherapies in mice.
Petersen J, Merrild C, Lund J, Holm S, Clemmensen C. Petersen J, et al. Mol Metab. 2024 Nov;89:102027. doi: 10.1016/j.molmet.2024.102027. Epub 2024 Sep 13. Mol Metab. 2024. PMID: 39265725 Free PMC article.
These benefits were not observed with the MC4R agonist, setmelanotide. CONCLUSIONS: Our findings provide compelling evidence that calorie restriction prior to incretin-based therapy enhances the achievable extent of weight loss, as reflected in a weight loss plateau at a l …
These benefits were not observed with the MC4R agonist, setmelanotide. CONCLUSIONS: Our findings provide compelling evidence that cal …
Human-induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation in vitro after abbreviated gonadotropin stimulation.
Piechota S, Marchante M, Giovannini A, Paulsen B, Potts KS, Rockwell G, Aschenberger C, Noblett AD, Figueroa AB, Sanchez M, Barrachina F, Wiemer K, Guzman L, Belchin P, Pierson Smela M, Fortuna PRJ, Chatterjee P, Tran ND, Kelk DA, Forti M, Marcinyshyn S, Smith T, McCulloh DH, Fernandez-Gonzalez MJ, Abittan B, Ortiz S, Klein JU, Klatsky P, Ordonez-Perez D, Kramme CC. Piechota S, et al. Hum Reprod. 2023 Dec 4;38(12):2456-2469. doi: 10.1093/humrep/dead205. Hum Reprod. 2023. PMID: 37815487 Free PMC article.
LIMITATIONS, REASONS FOR CAUTION: While the findings of this study are compelling, the cohort size remains limited and was powered on preliminary pilot studies, and the basic research nature of the study limits generalizability compared to randomized control trials. ...
LIMITATIONS, REASONS FOR CAUTION: While the findings of this study are compelling, the cohort size remains limited and was powered on …
Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.
Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, Cai Z, Xie N, Huang S, Liu Z, Mo X, Guan Y, Wang X, Fu Y, Ma D, Wang Y, Kong W. Wang Y, et al. Circulation. 2018 Jul 3;138(1):48-63. doi: 10.1161/CIRCULATIONAHA.117.032398. Epub 2018 Feb 16. Circulation. 2018. PMID: 29453251
However, the mechanisms that link obesity and cardiovascular diseases remain elusive. Compelling evidence indicates that adipokines play an important role in obesity-related cardiovascular diseases. Here, we found a new adipokine-named family with sequence similarity 19, m …
However, the mechanisms that link obesity and cardiovascular diseases remain elusive. Compelling evidence indicates that adipokines p …
Sequential management of postmenopausal health and osteoporosis: An update.
Calaf-Alsina J, Cano A, Guañabens N, Palacios S, Cancelo MJ, Castelo-Branco C, Larrainzar-Garijo R, Neyro JL, Nogues X, Diez-Perez A. Calaf-Alsina J, et al. Maturitas. 2023 Nov;177:107846. doi: 10.1016/j.maturitas.2023.107846. Epub 2023 Sep 13. Maturitas. 2023. PMID: 37738717 Free article. Review.
When the use of these agents is not possible, compelling evidence supports antiresorptive agents as first-line treatment of postmenopausal osteoporosis in many clinical scenarios, with digestive conditions, kidney function, readiness for compliance, or patient preferences …
When the use of these agents is not possible, compelling evidence supports antiresorptive agents as first-line treatment of postmenop …
Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4.
Maspero E, Cappa A, Weber J, Trifirò P, Amici R, Bruno A, Fagà G, Cecatiello V, Fattori R, Leuzzi B, Taibi V, Meroni G, Pasi M, Romussi A, Sartori L, Villa M, Vultaggio S, Cirò M, Soffientini P, Lombardo L, Dahe S, Bachi A, Varasi M, Rossi M, Pasqualato S, Mercurio C, Polo S. Maspero E, et al. Commun Chem. 2025 May 28;8(1):164. doi: 10.1038/s42004-025-01557-4. Commun Chem. 2025. PMID: 40437006 Free PMC article.
Among the human E3 ubiquitin ligases, NEDD4 (Neural precursor cell expressed developmentally down-regulated 4) plays a critical role in development and cancer, making it a compelling therapeutic target. However, no specific NEDD4 inhibitors have advanced in drug developmen …
Among the human E3 ubiquitin ligases, NEDD4 (Neural precursor cell expressed developmentally down-regulated 4) plays a critical role in deve …
Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8 + TILs function and recruiting B cells in cervical cancer.
Jiang L, Wu T, Qu X, Li S, Jiang Q, Ren T, Liang J, Ding Y, Hua K, Tang Z, Qiu J. Jiang L, et al. J Nanobiotechnology. 2025 Jun 3;23(1):413. doi: 10.1186/s12951-025-03500-0. J Nanobiotechnology. 2025. PMID: 40462160 Free PMC article.
Although the programmed cell death protein 1 (PD-1) blockade has been authorized for the treatment of recurrent and metastatic cervical cancer (CC) patients, a significant proportion of CC patients show low objective response rates (ORR) to immune checkpoint blockad …
Although the programmed cell death protein 1 (PD-1) blockade has been authorized for the treatment of recurrent and metastatic cervical canc …
Prioritization of Eleven-Nineteen-Leukemia Inhibitors as Orally Available Drug Candidates for Acute Myeloid Leukemia.
Guo XS, Atla S, Nyalata S, Alugubelli YR, Chen PC, Xu S, Liu WR. Guo XS, et al. J Med Chem. 2024 Nov 28;67(22):20100-20117. doi: 10.1021/acs.jmedchem.4c01337. Epub 2024 Nov 12. J Med Chem. 2024. PMID: 39530508 Free PMC article.
Subsequent optimization efforts led to the development of SR-C-107 (R), which exhibited strong activity against AML both at the cellular level (CC(50 (MOLM-13)): 1.25 0.18 muM; CC(50 (MV4-11)): 0.81 0.15 muM) and in vivo. These findings establish SR-C-107 (R) as a …
Subsequent optimization efforts led to the development of SR-C-107 (R), which exhibited strong activity against AML both at the cellular lev …
Organoids research progress in gynecological cancers: a bibliometric analysis.
He B, Ma H, Yu H, Li D, Zhang L, Wang J. He B, et al. Front Oncol. 2024 Oct 28;14:1484074. doi: 10.3389/fonc.2024.1484074. eCollection 2024. Front Oncol. 2024. PMID: 39529835 Free PMC article.
Additionally, as preclinical models, they provide compelling evidence for personalized therapy and prediction of patient drug responses....
Additionally, as preclinical models, they provide compelling evidence for personalized therapy and prediction of patient drug respons …
Cross-Sectional Analysis of Outer Retinal Tubulation in Inherited Retinal Diseases: A Multicenter Study.
Liu PK, Lee W, Su PY, Kim AH, Kang EY, Levi SR, Jenny LA, Lin PH, Chi YC, Wu PL, Wang EH, Chang YC, Liu L, Chen KJ, Hwang YS, Wu WC, Lai CC, Tsang SH, Allikmets R, Wang NK. Liu PK, et al. Am J Ophthalmol. 2025 Jan;269:116-135. doi: 10.1016/j.ajo.2024.07.032. Epub 2024 Aug 8. Am J Ophthalmol. 2025. PMID: 39127396
CONCLUSIONS: These results illustrate a compelling association between the presence of ORT and IRDs caused by variants in RPE-specific genes, as well as non-RPE-specific genes. ...
CONCLUSIONS: These results illustrate a compelling association between the presence of ORT and IRDs caused by variants in RPE-specifi …
213 results