Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb;28(2):1069-1078.
doi: 10.1245/s10434-020-08679-0. Epub 2020 Jun 8.

A Standard Set of Value-Based Patient-Centered Outcomes for Pancreatic Carcinoma: An International Delphi Survey

Zineb Cherkaoui  1   2   3 , Cristians González  1   2 , Taiga Wakabayashi  4 , Bastien Delattre  5 , Elodie Léost  5 , Sébastien Serra  6 , Jerôme Huppertz  6 , Francine Klein  2 , Marie Stéphan  2 , Jean-Michel Meyer  7 , Alain Schaff  2 , Elisa Martinis  2 , Elena Bangoura  2 , Sophie Kieffer  2 , Sophie Blanès  2 , Elham Haddad  8 , Gabrielle De Guio  9 , Emanuele Felli  2 , Sophie Pernot  1 , Jacques Marescaux  1   4 , Didier Mutter  1   2   4 , Constance Lugiez  5 , Patrick Pessaux  10   11   12   13   14 ; IHU-VBHC Working Group
Collaborators, Affiliations

A Standard Set of Value-Based Patient-Centered Outcomes for Pancreatic Carcinoma: An International Delphi Survey

Zineb Cherkaoui et al. Ann Surg Oncol. 2021 Feb.

Abstract

Background: Global health systems are shifting toward value-based health care to improve patient outcomes in the face of rising health care costs. The challenge is to identify standardized outcome measurements that allow optimal quality-of-care monitoring and comparison to optimize medical practices and patient pathways. A common outcomes definition is required, including medical results (Clinical Reported Outcomes Measurements [CROMs]) and quality-of-life components that matter most to patients (Patient-Reported Outcomes Measurements [PROMs]), which are particularly important for severe pathologies with short life expectancy such as pancreatic cancer. This study aimed to create standardized metrics that could be used for outcomes analysis of pancreatic cancer care.

Methods: A multidisciplinary working group (WG) was assembled. A systematic review was performed to collect the most used outcomes in clinical studies of pancreatic cancers. The study reviewed 570 studies published in the last 10 years. From these studies, 3370 outcomes, including CROMs, and PROMs, were listed and prioritized. The WG reached a consensus on key outcomes, proposed groupings for CROMs and PROMs, identified existing questionnaires that could be used for PROMs collection, and set the timeline for data collection. To refine and validate the final outcomes set, an international external committee completed a Delphi process (two rounds for both CROMS and PROMs).

Results: After the systematic literature review, the WG selected 102 outcomes (92 CROMs and 10 PROMs) for submission to the international Delphi vote committee. The committee retrained 89 outcomes (78 CROMs and 11 PROMs). For the PROMs, the WG and the international external committee chose a validated questionnaire, the Functional Assessment of Cancer Therapy-Hepatobiliary, which covers all of the 11 selected PROMs.

Conclusions: A standardized set of outcome measures that need to be validated through international health outcome comparisons and quality-of-care assessments was built. Pilot projects are underway to test and optimize the approach in real-life conditions.

PubMed Disclaimer

References

    1. Bardou M, Le Ray I. Treatment of pancreatic cancer: a narrative review of cost-effectiveness studies. Best Pract Res Clin Gastroenterol. 2013;27:881–92. - DOI
    1. Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol. 2016;22:9694–705. - DOI
    1. Neuzillet C, Gaujoux S, Williet N, Bachet JB, Bauguion L, Colson Durand L, et al; Thésaurus National de Cancérologie Digestive (TNCD); Société Nationale Française de Gastroentérologie (SNFGE); Fédération Francophone de Cancérologie Digestive (FFCD); Groupe Coopérateur multidisciplinaire en Oncologie (GERCOR); Fédération Nationale des Centres de Lutte Contre le Cancer (UNICANCER); Société Française de Chirurgie Digestive (SFCD); Société Française d’Endoscopie Digestive (SFED); Société Française de Radiothérapie Oncologique (SFRO); Association de Chirurgie Hépato-Bilio-Pancréatique et Transplantation (ACHBT); Association Française de Chirurgie (AFC). Pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC). Dig Liver Dis. 2018;50:1257–71.
    1. Porter ME. A strategy for health care reform: toward a value-based system. N Engl J Med. 2009;361:109–12. - DOI
    1. Pessaux P, Cherkaoui Z. Value-based healthcare: a novel approach to the evaluation of patient care. Hepatobiliary Surg Nutr. 2018;7:125–6. - DOI

Publication types

LinkOut - more resources