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Comparative Study
. 2013 Aug 20:13:382.
doi: 10.1186/1471-2334-13-382.

All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997-2010

Victoria Hernando  1 , Belen Alejos, Susana Monge, Juan Berenguer, Lourdes Anta, David Vinuesa, Rosario Palacios, Roberto Muga, Santiago Moreno, Inma Jarrin; CoRIS cohort
Collaborators, Affiliations
Comparative Study

All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997-2010

Victoria Hernando et al. BMC Infect Dis. .

Abstract

Background: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population.

Methods: We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender.

Results: Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997-2003).

Conclusion: Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection.

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Figures

Figure 1
Figure 1
Mortality rates per 100 person-years of follow-up, Standardized mortality ratio (SMRs) and excess mortality rates per 100 person-years of follow-up according to sociodemographic, epidemiological and clinical characteristics.
See this image and copyright information in PMC

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