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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 2
1981 1
1982 1
1983 1
1984 3
1985 3
1987 8
1988 9
1989 9
1990 12
1991 10
1992 6
1993 10
1994 8
1995 9
1996 11
1997 10
1998 8
1999 2
2000 9
2001 5
2002 12
2003 9
2004 9
2005 7
2006 8
2007 7
2008 11
2009 15
2010 15
2011 13
2012 11
2013 8
2014 10
2015 10
2016 16
2017 13
2018 10
2019 9
2020 13
2021 16
2022 10
2023 15
2024 5
2025 9

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378 results

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Page 1
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik … See abstract for full author list ➔ Gordon DE, et al. Among authors: craik cs. Nature. 2020 Jul;583(7816):459-468. doi: 10.1038/s41586-020-2286-9. Epub 2020 Apr 30. Nature. 2020. PMID: 32353859 Free PMC article.
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
Jain A, Heremans I, Rademaker G, Detomasi TC, Rohweder P, Anderson D, Zhang J, Hernandez GA, Gupta S, von Linde T, Lange M, Spacci M, Luo J, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, Zoncu R. Jain A, et al. Among authors: craik cs. Science. 2025 Mar 28;387(6741):eadq8331. doi: 10.1126/science.adq8331. Epub 2025 Mar 28. Science. 2025. PMID: 40146846 Free article.
Preparing for the next pandemic.
Shoichet BK, Craik CS. Shoichet BK, et al. Among authors: craik cs. Science. 2023 Nov 10;382(6671):649-650. doi: 10.1126/science.adk5868. Epub 2023 Nov 9. Science. 2023. PMID: 37943911 Free PMC article.
Engineering enzyme specificity.
Harris JL, Craik CS. Harris JL, et al. Among authors: craik cs. Curr Opin Chem Biol. 1998 Feb;2(1):127-32. doi: 10.1016/s1367-5931(98)80044-6. Curr Opin Chem Biol. 1998. PMID: 9667915 Review.
Proteases as therapeutics.
Craik CS, Page MJ, Madison EL. Craik CS, et al. Biochem J. 2011 Apr 1;435(1):1-16. doi: 10.1042/BJ20100965. Biochem J. 2011. PMID: 21406063 Free PMC article. Review.
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy.
Detomasi TC, Degotte G, Huang S, Suryawanshi RK, Diallo A, Lizzadro L, Zapatero-Belinchón FJ, Taha TY, Li J, Richards AL, Hantz ER, Alam Z, Montano M, McCavitt-Malvido M, Gumpena R, Partridge JR, Correy GJ, Matsui Y, Charvat AF, Glenn IS, Rosecrans J, Revalde JL, Anderson D, Hultquist JF, Arkin MR, Neitz RJ, Swaney DL, Krogan NJ, Shoichet BK, Verba KA, Ott M, Renslo AR, Craik CS. Detomasi TC, et al. Among authors: craik cs. Sci Adv. 2025 Apr 25;11(17):eadt7836. doi: 10.1126/sciadv.adt7836. Epub 2025 Apr 23. Sci Adv. 2025. PMID: 40267184 Free PMC article.
Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
Jain A, Heremans I, Rademaker G, Detomasi TC, Hernandez GA, Zhang J, Gupta S, von Linde T, Lange M, Spacci M, Rohweder P, Anderson D, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, Zoncu R. Jain A, et al. Among authors: craik cs. bioRxiv [Preprint]. 2024 Dec 14:2024.12.13.628212. doi: 10.1101/2024.12.13.628212. bioRxiv. 2024. Update in: Science. 2025 Mar 28;387(6741):eadq8331. doi: 10.1126/science.adq8331. PMID: 39713462 Free PMC article. Updated. Preprint.
378 results