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. 1994 Jul 11;22(13):2476-8.
doi: 10.1093/nar/22.13.2476.

Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120

E V Koonin  1
Affiliations
Free PMC article

Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120

E V Koonin. Nucleic Acids Res. .
Free PMC article

Abstract

Using computer methods for identification of amino acid motifs in sequence databases and multiple alignment, it is shown that human proliferation-associated nucleolar protein P120 contains a putative methyltransferase domain that is conserved in a group of bacterial proteins. It is hypothesized that P120 and the related prokaryotic proteins are rRNA methylases required for division of all types of cells.

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