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. 2006 Jul;50(7):2573-6.
doi: 10.1128/AAC.01633-05.

Naturally occurring extended-spectrum cephalosporinases in Escherichia coli

Hedi Mammeri  1 , Laurent Poirel, Nicolas Fortineau, Patrice Nordmann
Affiliations

Naturally occurring extended-spectrum cephalosporinases in Escherichia coli

Hedi Mammeri et al. Antimicrob Agents Chemother. 2006 Jul.

Abstract

Genetic and functional characterization of the cephalosporinases produced by 65 clonally unrelated clinical Escherichia coli isolates revealed genetic diversity of the ampC genes and showed that Gln287, Cys287, Pro296, Leu298, and Phe350 substitutions were involved in extension of the hydrolysis spectrum to include ceftazidime and cefepime.

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Figures

FIG. 1.
FIG. 1.
Phylogeny of the chromosomal ampC gene of the 65 E. coli isolates studied. The tree was obtained by the parsimony method. Three major groups are shown. ampC genes coding for ESAC β-lactamases are boxed. The phylogroups of the E. coli strains are indicated by brackets.
See this image and copyright information in PMC

References

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