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Multicenter Study
. 2024 Oct 14;16(11):1119-1124.
doi: 10.1136/jnis-2023-020909.

Location specific rupture risk of intracranial aneurysms: case of ophthalmic aneurysms

Pierre-Marie Chiaroni  1 , Xavier Guerra  1   2 , Jonathan Cortese  3 , Julien Burel  4 , Thomas Courret  5 , Pacome Constant Dit Beaufils  6 , Thibault Agripnidis  7 , Ian Leonard-Lorant  8 , Cédric Fauché  9 , Nourou Dine Adeniran Bankole  10 , Géraud Forestier  11 , Vincent L'allinec  12 , Peter B Sporns  13   14 , Gaelle Gueton  15 , Nico Lorena  15 , Marios-Nikos Psychogios  13 , Jean-Baptiste Girot  12 , Aymeric Rouchaud  11   16 , Kevin Janot  10 , Nicolas Raynaud  9 , Raoul Pop  8 , Jean-Francois Hak  7 , Basile Kerleroux  2 , Romain Bourcier  6 , Gaultier Marnat  5 , Chrysanthi Papagiannaki  4 , Nader-Antoine Sourour  1 , Frédéric Clarençon  1   17 , Eimad Shotar  18   19 ; JENI Research Collaboration
Collaborators, Affiliations
Multicenter Study

Location specific rupture risk of intracranial aneurysms: case of ophthalmic aneurysms

Pierre-Marie Chiaroni et al. J Neurointerv Surg. .

Abstract

Background: Aneurysm location is a key element in predicting the rupture risk of an intracranial aneurysm. A common impression suggests that pure ophthalmic aneurysms are under-represented in ruptured intracranial aneurysms (RIAs). The purpose of this study was to specifically evaluate the risk of rupture of ophthalmic aneurysms compared with other aneurysm locations.

Methods: This multicenter study compared the frequency of ophthalmic aneurysms in a prospective cohort of RIAs admitted to 13 neuroradiology centers between January 2021 and March 2021, with a retrospective cohort of patients with unruptured intracranial aneurysms (UIAs) who underwent cerebral angiography at the same neuroradiology centers during the same time period.

Results: 604 intracranial aneurysms were included in this study (355 UIAs and 249 RIAs; mean age 57 years (IQR 49-65); women 309/486, 64%). Mean aneurysm size was 6.0 mm (5.3 mm for UIAs, 7.0 mm for RIAs; P<0.0001). Aneurysm shape was irregular for 37% UIAs and 73% RIAs (P<0.0001). Ophthalmic aneurysms frequency was 14.9% of UIAs (second most common aneurysm location) and 1.2% of RIAs (second least common aneurysm location; OR 0.07 (95% CI 0.02 to 0.23), P<0.0001).

Conclusions: Ophthalmic aneurysms seem to have a low risk of rupture compared with other intracranial aneurysm locations. This calls for a re-evaluation of the benefit-risk balance when considering preventive treatment for ophthalmic aneurysms.

Keywords: Aneurysm.

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Conflict of interest statement

Competing interests: FC is a consultant for Medtronic, Balt Extrusion, Penumbra, Microvention, and Stryker; board member of Artedrone, and has stock options with Intradys and Collavidence. GM is a consultant for Stryker Neurovascular, Balt, Microvention Europe, and Sim and Cure, and has done paid lectures for Medtronic, Phenox, Johnson & Johnson, and Bracco. KJ is a consultant for Balt. AR is a consultant for Balt, Medtronic, Microvention, and Stryker. N-AS is a consultant for Balt, Medtronic Extrusion, and Microvention.

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