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Page 1
Showing results for deplete t
Search for Detente T instead (2 results)
Preclinical development of a novel CCR8/CTLA-4 bispecific antibody for cancer treatment by disrupting CTLA-4 signaling on CD8 T cells and specifically depleting tumor-resident Tregs.
Guo C, Dai X, Du Y, Xiong X, Gui X. Guo C, et al. Cancer Immunol Immunother. 2024 Aug 9;73(10):210. doi: 10.1007/s00262-024-03794-3. Cancer Immunol Immunother. 2024. PMID: 39123089 Free PMC article.
Anti-CTLA-4 antibodies faced challenges due to frequent adverse events and limited efficacy, which spurred the exploration of next-generation CTLA-4 therapeutics to balance regulatory T cells (Tregs) depletion and CD8 T cells activation. CCR8, identified prim …
Anti-CTLA-4 antibodies faced challenges due to frequent adverse events and limited efficacy, which spurred the exploration of next-generatio …
CD20(+) T cells: an emerging T cell subset in human pathology.
Lee AYS. Lee AYS. Inflamm Res. 2022 Nov;71(10-11):1181-1189. doi: 10.1007/s00011-022-01622-x. Epub 2022 Aug 11. Inflamm Res. 2022. PMID: 35951029 Free PMC article. Review.
Articles in English were considered, and there was no time restriction. RESULTS: CD20(+) T cells express the standard T cell markers and, in comparison to CD20 T cells, appear to express greater inflammatory cytokines and markers of effector function. ...One …
Articles in English were considered, and there was no time restriction. RESULTS: CD20(+) T cells express the standard T cell m …
Ego depletion and the strength model of self-control: a meta-analysis.
Hagger MS, Wood C, Stiff C, Chatzisarantis NL. Hagger MS, et al. Psychol Bull. 2010 Jul;136(4):495-525. doi: 10.1037/a0019486. Psychol Bull. 2010. PMID: 20565167
Results revealed a significant effect of ego depletion on self-control task performance. Significant effect sizes were found for ego depletion on effort, perceived difficulty, negative affect, subjective fatigue, and blood glucose levels. ...Motivational incentives, …
Results revealed a significant effect of ego depletion on self-control task performance. Significant effect sizes were found for ego …
Treatment with immunotoxin.
Knechtle SJ. Knechtle SJ. Philos Trans R Soc Lond B Biol Sci. 2001 May 29;356(1409):681-9. doi: 10.1098/rstb.2001.0839. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11375071 Free PMC article. Review.
Both total lymphoid irradiation and anti-lymphocyte globulin have been used for this purpose in experimental models of transplantation as well as in human organ transplant recipients. However, these methods of T-cell depletion are limited in their ability to depl …
Both total lymphoid irradiation and anti-lymphocyte globulin have been used for this purpose in experimental models of transplantation as we …
Depleting T-cell subpopulations in organ transplantation.
Haudebourg T, Poirier N, Vanhove B. Haudebourg T, et al. Transpl Int. 2009 May;22(5):509-18. doi: 10.1111/j.1432-2277.2008.00788.x. Epub 2008 Oct 30. Transpl Int. 2009. PMID: 18980625 Free article. Review.
T-cell depletion strategies are an efficient therapy for the treatment of acute rejection after organ transplantation and have been successfully used as induction regimens. Although eliminating whole T cells blocks alloreactivity, this therapy challenges the …
T-cell depletion strategies are an efficient therapy for the treatment of acute rejection after organ transplantation and have …
T-cell depleting antibodies: new hope for induction of allograft tolerance in bone marrow transplantation?
Simpson D. Simpson D. BioDrugs. 2003;17(3):147-54. doi: 10.2165/00063030-200317030-00001. BioDrugs. 2003. PMID: 12749751 Review.
Alternative approaches are needed. In vivo T-cell depletion, using antithymocyte globulin (ATG) as part of the conditioning regimen, seems an attractive option. Pre-transplant ATG lingers in the bone marrow to deplete engrafting donor T cells, but also …
Alternative approaches are needed. In vivo T-cell depletion, using antithymocyte globulin (ATG) as part of the conditioning re …
CD25-targeted antibody-drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity.
Zammarchi F, Havenith K, Bertelli F, Vijayakrishnan B, Chivers S, van Berkel PH. Zammarchi F, et al. J Immunother Cancer. 2020 Sep;8(2):e000860. doi: 10.1136/jitc-2020-000860. J Immunother Cancer. 2020. PMID: 32912922 Free PMC article.
Numerous strategies have been attempted to deplete or block T(regs), although their success has been limited. METHODS: A CD25-targeted, pyrrolobenzodiazepine (PBD) dimer-based antibody-drug conjugate (ADC) was investigated for its ability to deplete T( …
Numerous strategies have been attempted to deplete or block T(regs), although their success has been limited. METHODS: A CD25- …
In vivo application of mAb directed against the gammadelta TCR does not deplete but generates "invisible" gammadelta T cells.
Koenecke C, Chennupati V, Schmitz S, Malissen B, Förster R, Prinz I. Koenecke C, et al. Eur J Immunol. 2009 Feb;39(2):372-9. doi: 10.1002/eji.200838741. Eur J Immunol. 2009. PMID: 19130484 Free article.
mAb targeting the gammadelta TCR have been used for gammadelta T-cell depletion with varying success. Although the depletion-capacity of the anti-gammadelta TCR mAb clone GL3 has been disputed repeatedly, many groups continue to use gammadelta T-cell …
mAb targeting the gammadelta TCR have been used for gammadelta T-cell depletion with varying success. Although the depletio …
A CD25TIGIT bispecific antibody induces anti-tumor activity through selective intratumoral Treg cell depletion.
Wei X, Zhao L, Yang F, Yang Y, Zhang H, Du K, Tian X, Fan R, Si G, Wang K, Li Y, Wei Z, He M, Sui J. Wei X, et al. Mol Ther. 2024 Nov 6;32(11):4075-4094. doi: 10.1016/j.ymthe.2024.09.010. Epub 2024 Sep 7. Mol Ther. 2024. PMID: 39245938 Free PMC article.
Intratumoral regulatory T cells (Tregs) express high levels of CD25 and TIGIT, which are also recognized as markers of effector T cell (Teff) activation. Targeting these molecules each alone with monoclonal antibodies (mAbs) poses a risk of concurrently depleting …
Intratumoral regulatory T cells (Tregs) express high levels of CD25 and TIGIT, which are also recognized as markers of effector T …
Innovative treatment approaches for rheumatoid arthritis. T-cell regulation.
Choy EH, Kingsley GH, Panayi GS. Choy EH, et al. Baillieres Clin Rheumatol. 1995 Nov;9(4):653-71. doi: 10.1016/s0950-3579(05)80307-3. Baillieres Clin Rheumatol. 1995. PMID: 8591647 Review.
Several strategies targeting T cells have been tried in RA. The use of monoclonal antibodies to deplete T cells have been used extensively but with little success. ...The mechanism of action of oral tolerance involves either immunosuppressive T cell cy …
Several strategies targeting T cells have been tried in RA. The use of monoclonal antibodies to deplete T cells have be …
160,068 results
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