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2000 1
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89 results

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Page 1
Rebuttal From Dr Downey.
Downey DG. Downey DG. Chest. 2022 Jan;161(1):24. doi: 10.1016/j.chest.2021.06.019. Chest. 2022. PMID: 35000703 No abstract available.
Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial.
Heijerman HGM, McKone EF, Downey DG, Van Braeckel E, Rowe SM, Tullis E, Mall MA, Welter JJ, Ramsey BW, McKee CM, Marigowda G, Moskowitz SM, Waltz D, Sosnay PR, Simard C, Ahluwalia N, Xuan F, Zhang Y, Taylor-Cousar JL, McCoy KS; VX17-445-103 Trial Group. Heijerman HGM, et al. Among authors: downey dg. Lancet. 2019 Nov 23;394(10212):1940-1948. doi: 10.1016/S0140-6736(19)32597-8. Epub 2019 Oct 31. Lancet. 2019. PMID: 31679946 Free PMC article. Clinical Trial.
ECFS standards of care on CFTR-related disorders: Identification and care of the disorders.
Simmonds NJ, Southern KW, De Wachter E, De Boeck K, Bodewes F, Mainz JG, Middleton PG, Schwarz C, Vloeberghs V, Wilschanski M, Bourrat E, Chalmers JD, Ooi CY, Debray D, Downey DG, Eschenhagen P, Girodon E, Hickman G, Koitschev A, Nazareth D, Nick JA, Peckham D, VanDevanter D, Raynal C, Scheers I, Waller MD, Sermet-Gaudelus I, Castellani C; ECFS Diagnostic Network Working Group. Simmonds NJ, et al. Among authors: downey dg. J Cyst Fibros. 2024 Jul;23(4):590-602. doi: 10.1016/j.jcf.2024.03.008. Epub 2024 Mar 19. J Cyst Fibros. 2024. PMID: 38508949 Free article.
Practical Guidance for Clinical Microbiology Laboratories: Updated guidance for processing respiratory tract samples from people with cystic fibrosis.
Saiman L, Waters V, LiPuma JJ, Hoffman LR, Alby K, Zhang SX, Yau YC, Downey DG, Sermet-Gaudelus I, Bouchara J-P, Kidd TJ, Bell SC, Brown AW. Saiman L, et al. Among authors: downey dg. Clin Microbiol Rev. 2024 Sep 12;37(3):e0021521. doi: 10.1128/cmr.00215-21. Epub 2024 Aug 19. Clin Microbiol Rev. 2024. PMID: 39158301 Free PMC article. Review.
Hypertonic Saline or Carbocisteine in Bronchiectasis.
Bradley JM, O'Neill B, McAuley DF, Chalmers JD, De Soyza A, Hill AT, Carroll M, Loebinger MR, Duckers J, Clarke M, McLeese RH, Ferguson K, Jackson A, Campbell C, McDowell C, Agus A, Norrie J, Copeland F, Downey DG, Convery R, Kelly M, Flight W, Talbot NP, Hurst JR, Steer J, Anwar M, Shahidi M, Gatheral T, Etumi M, Sullivan AL, Ionescu AA, Patil V, Bhattacharya M, Caskey S, Cosgrove D, Hagan C, Shoemark A, McManus T, Davies G, Elborn JS; CLEAR Investigator Team. Bradley JM, et al. Among authors: downey dg. N Engl J Med. 2025 Oct 23;393(16):1565-1577. doi: 10.1056/NEJMoa2510095. Epub 2025 Sep 28. N Engl J Med. 2025. PMID: 41020514 Clinical Trial.
Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial.
Sutharsan S, McKone EF, Downey DG, Duckers J, MacGregor G, Tullis E, Van Braeckel E, Wainwright CE, Watson D, Ahluwalia N, Bruinsma BG, Harris C, Lam AP, Lou Y, Moskowitz SM, Tian S, Yuan J, Waltz D, Mall MA; VX18-445-109 study group. Sutharsan S, et al. Among authors: downey dg. Lancet Respir Med. 2022 Mar;10(3):267-277. doi: 10.1016/S2213-2600(21)00454-9. Epub 2021 Dec 20. Lancet Respir Med. 2022. PMID: 34942085 Clinical Trial.
Theratyping in cystic fibrosis.
Crawford KJ, Downey DG. Crawford KJ, et al. Among authors: downey dg. Curr Opin Pulm Med. 2018 Nov;24(6):612-617. doi: 10.1097/MCP.0000000000000521. Curr Opin Pulm Med. 2018. PMID: 30124524 Review.
Tackling bias in clinical trials.
van Koningsbruggen-Rietschel S, Downey DG. van Koningsbruggen-Rietschel S, et al. Among authors: downey dg. J Cyst Fibros. 2019 Jul;18(4):445-446. doi: 10.1016/j.jcf.2019.06.001. J Cyst Fibros. 2019. PMID: 31230796 Free article. No abstract available.
Managing an ageing cystic fibrosis population: challenges and priorities.
Frost FJ, Peckham DG, Felton IC, Snowball JE, Gray RD, Jones AM, Simmonds NJ, Lord RW, Lip GYH, Chandler H, Murphy K, Downey DG, Sheppard DN, Davies JC, Bull J, Sommer P, Cupid B, Allen L, Duckers J. Frost FJ, et al. Among authors: downey dg. Eur Respir Rev. 2025 May 14;34(176):240261. doi: 10.1183/16000617.0261-2024. Print 2025 Apr. Eur Respir Rev. 2025. PMID: 40368426 Free PMC article. Review.
89 results