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Year Number of Results
1959 1
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1966 1
1972 1
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1976 1
1978 1
1980 1
1984 1
1988 3
1989 1
1991 1
1992 2
1994 1
1995 1
1996 2
1997 4
1998 3
1999 3
2000 11
2001 1
2002 3
2003 2
2004 7
2005 10
2006 11
2007 11
2008 22
2009 14
2010 14
2011 15
2012 13
2013 14
2014 24
2015 24
2016 22
2017 25
2018 28
2019 31
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2021 35
2022 44
2023 30
2024 22
2025 26

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461 results

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Page 1
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Logan T, Simon MJ, Rana A, Cherf GM, Srivastava A, Davis SS, Low RLY, Chiu CL, Fang M, Huang F, Bhalla A, Llapashtica C, Prorok R, Pizzo ME, Calvert MEK, Sun EW, Hsiao-Nakamoto J, Rajendra Y, Lexa KW, Srivastava DB, van Lengerich B, Wang J, Robles-Colmenares Y, Kim DJ, Duque J, Lenser M, Earr TK, Nguyen H, Chau R, Tsogtbaatar B, Ravi R, Skuja LL, Solanoy H, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Dennis MS, Kariolis MS, Monroe KM, Przybyla L, Sanchez PE, Meisner R, Diaz D, Henne KR, Watts RJ, Henry AG, Gunasekaran K, Astarita G, Suh JH, Lewcock JW, DeVos SL, Di Paolo G. Logan T, et al. Among authors: duque j. Cell. 2021 Sep 2;184(18):4651-4668.e25. doi: 10.1016/j.cell.2021.08.002. Epub 2021 Aug 26. Cell. 2021. PMID: 34450028 Free PMC article.
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, Capell A, Davis SS, de Weerd L, Dugas JC, Duque J, Earr T, Gadkar K, Giese T, Gill A, Gnörich J, Ha C, Kannuswamy M, Kim DJ, Kunte ST, Kunze LH, Lac D, Lechtenberg K, Leung AW, Liang CC, Lopez I, McQuade P, Modi A, Torres VO, Nguyen HN, Pesämaa I, Propson N, Reich M, Robles-Colmenares Y, Schlepckow K, Slemann L, Solanoy H, Suh JH, Thorne RG, Vieira C, Wind-Mark K, Xiong K, Zuchero YJY, Diaz D, Dennis MS, Huang F, Scearce-Levie K, Watts RJ, Haass C, Lewcock JW, Di Paolo G, Brendel M, Sanchez PE, Monroe KM. van Lengerich B, et al. Among authors: duque j. Nat Neurosci. 2023 Mar;26(3):416-429. doi: 10.1038/s41593-022-01240-0. Epub 2023 Jan 12. Nat Neurosci. 2023. PMID: 36635496 Free PMC article.
Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Pizzo ME, Plowey ED, Khoury N, Kwan W, Abettan J, DeVos SL, Discenza CB, Earr T, Joy D, Lye-Barthel M, Roche E, Chan D, Dugas JC, Gadkar K, Hamann S, Meisner R, Sebalusky J, Silva Amaral AC, Becerra I, Chau R, Chow J, Clemens AJ, Dennis MS, Duque J, Fusaro L, Getz JA, Kariolis MS, Kim DJ, Lechtenberg KJ, Leung AW, Moshkforoush A, Nguyen HN, Ojo ES, Thomsen ER, Torres VO, Sanchez PE, Shan L, Silverman AP, Sweeney ZK, Solanoy H, Tong R, Calvert ME, Watts RJ, Thorne RG, Weinreb PH, Walsh DM, Lewcock JW, Bussiere T, Zuchero YJY. Pizzo ME, et al. Among authors: duque j. Science. 2025 Aug 7;389(6760):eads3204. doi: 10.1126/science.ads3204. Epub 2025 Aug 7. Science. 2025. PMID: 40773560
CD98hc is a target for brain delivery of biotherapeutics.
Chew KS, Wells RC, Moshkforoush A, Chan D, Lechtenberg KJ, Tran HL, Chow J, Kim DJ, Robles-Colmenares Y, Srivastava DB, Tong RK, Tong M, Xa K, Yang A, Zhou Y, Akkapeddi P, Annamalai L, Bajc K, Blanchette M, Cherf GM, Earr TK, Gill A, Huynh D, Joy D, Knight KN, Lac D, Leung AW, Lexa KW, Liau NPD, Becerra I, Malfavon M, McInnes J, Nguyen HN, Lozano EI, Pizzo ME, Roche E, Sacayon P, Calvert MEK, Daneman R, Dennis MS, Duque J, Gadkar K, Lewcock JW, Mahon CS, Meisner R, Solanoy H, Thorne RG, Watts RJ, Zuchero YJY, Kariolis MS. Chew KS, et al. Among authors: duque j. Nat Commun. 2023 Aug 19;14(1):5053. doi: 10.1038/s41467-023-40681-4. Nat Commun. 2023. PMID: 37598178 Free PMC article.
Outcomes of X-Linked Agammaglobulinaemia Patients.
Shillitoe B, Duque JSR, Lai SHY, Lau TM, Chan JCH, Bourne H, Stroud C, Flood T, Buckland M, Ip W, Worth A, Hackett S, Herwadkar A, Coulter T, Blaney C, Jolles S, Garcez T, Moya E, Faust S, Pearce MS, Lau YL, Gennery AR. Shillitoe B, et al. Among authors: duque jsr. J Clin Immunol. 2024 Nov 14;45(1):40. doi: 10.1007/s10875-024-01829-z. J Clin Immunol. 2024. PMID: 39541002
Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial.
ANDROMEDA-SHOCK-2 Investigators for the ANDROMEDA Research Network, Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR), and Latin American Intensive Care Network (LIVEN); Hernandez G, Ospina-Tascón GA, Kattan E, Ibarra-Estrada M, Ramasco F, Orozco N, Ramos K, Aldana JL, Ferri G, Hamzaoui O, De Backer D, Teboul JL, Vieillard-Baron A, Petri Damiani L, García-Gallardo GA, Morales S, Carmona Garcia P, Mendez R, Hernandez-Gilsoul T, Pérez-Nieto OR, Olea Vielba C, Ramos S, Dominguez D, Bruna M, David S, Wendel-Garcia PD, Galiana-Ivars M, Myatra SN, Messina A, Cecconi M, Pozo M, Amthauer M, Higuera E, Al Duhalib Z, Rico-Feijoo J, Ferrer-Gómez C, Pérez-Carbonell A, Martinez-Castro S, Redondo Calvo FJ, Vives M, Sanchez HF, Bilbao I, Fernandez P, Al-Fares A, Benitez-Cano A, Gonzalez C, Reyes LF, Rodriguez-Guillen JH, Cristino AV, Pendino JC, Ortiz G, Alonso-Gonzalez MC, Murias G, Aguirre-Ávalos G, Hernández L, Calderón Barajas ZA, Zarragoikoetxea I, Monnet X, Goury A, Mendonça Dos Santos T, Vallecilla L, Martins de Lima L, Sady E, Alegria L, Ostermann M, Bakker J, Biasi Cavalcanti A. ANDROMEDA-SHOCK-2 Investigators for the ANDROMEDA Research Network, Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR), and Latin American Intensive Care Network (LIVEN), et al. JAMA. 2025 Oct 29:e2520402. doi: 10.1001/jama.2025.20402. Online ahead of print. JAMA. 2025. PMID: 41159835
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Ullman JC, Arguello A, Getz JA, Bhalla A, Mahon CS, Wang J, Giese T, Bedard C, Kim DJ, Blumenfeld JR, Liang N, Ravi R, Nugent AA, Davis SS, Ha C, Duque J, Tran HL, Wells RC, Lianoglou S, Daryani VM, Kwan W, Solanoy H, Nguyen H, Earr T, Dugas JC, Tuck MD, Harvey JL, Reyzer ML, Caprioli RM, Hall S, Poda S, Sanchez PE, Dennis MS, Gunasekaran K, Srivastava A, Sandmann T, Henne KR, Thorne RG, Di Paolo G, Astarita G, Diaz D, Silverman AP, Watts RJ, Sweeney ZK, Kariolis MS, Henry AG. Ullman JC, et al. Among authors: duque j. Sci Transl Med. 2020 May 27;12(545):eaay1163. doi: 10.1126/scitranslmed.aay1163. Sci Transl Med. 2020. PMID: 32461331
Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.
Khoury N, Pizzo ME, Discenza CB, Joy D, Tatarakis D, Todorov MI, Negwer M, Ha C, De Melo GL, Sarrafha L, Simon MJ, Chan D, Chau R, Chew KS, Chow J, Clemens A, Robles-Colmenares Y, Dugas JC, Duque J, Kaltenecker D, Kane H, Leung A, Lozano E, Moshkforoush A, Roche E, Sandmann T, Tong M, Xa K, Zhou Y, Lewcock JW, Ertürk A, Thorne RG, Calvert MEK, Yu Zuchero YJ. Khoury N, et al. Among authors: duque j. Nat Commun. 2025 Feb 20;16(1):1822. doi: 10.1038/s41467-025-57108-x. Nat Commun. 2025. PMID: 39979268 Free PMC article.
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules.
Wells RC, Akkapeddi P, Chan D, Joy D, Moshkforoush A, Chau R, Chow J, Cherf GM, Chien EYT, Clemens A, Pizzo ME, Qerqez AN, Tran T, Becerra I, Dugas JC, Duque J, Earr TK, Huynh D, Kim DJ, Wing-Sze Leung A, Liang E, Nguyen HN, Robles-Colmenares Y, Kane H, Roche E, Sacayon P, Xa K, Solanoy H, Dennis MS, Lewcock JW, Watts RJ, Kariolis MS, Thorne RG, Koth CM, Calvert MEK, Yu Zuchero YJ, Chew KS. Wells RC, et al. Among authors: duque j. Cell Rep. 2025 Aug 26;44(8):116038. doi: 10.1016/j.celrep.2025.116038. Epub 2025 Jul 22. Cell Rep. 2025. PMID: 40705600 Free article.
461 results