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. 2007 Jun 15;44(12):1657-61.
doi: 10.1086/518287. Epub 2007 May 8.

Use of peripheral blood DNA for genotype antiretroviral resistance testing in drug-naive HIV-infected subjects

Ilaria Vicenti  1 , Francesca Razzolini, Francesco Saladini, Laura Romano, Maurizio Zazzi
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Use of peripheral blood DNA for genotype antiretroviral resistance testing in drug-naive HIV-infected subjects

Ilaria Vicenti et al. Clin Infect Dis. .

Abstract

Parallel analysis of peripheral blood mononuclear cell DNA and plasma RNA from 169 drug-naive human immunodeficiency virus-infected subjects revealed that evaluation of both compartments increases the sensitivity of detection of drug resistance-related mutations, compared with examination of either source alone. Peripheral blood mononuclear cell DNA may play a role in the surveillance of transmitted antiretroviral resistance.

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