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Case Reports
. 2010 Jul;48(7):2630-5.
doi: 10.1128/JCM.00588-10. Epub 2010 Jun 2.

Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: evidence for a European sequence variant

Friederike D von Loewenich  1 , Walter Geissdörfer, Claudia Disqué, Jens Matten, Georg Schett, Samir G Sakka, Christian Bogdan
Affiliations
Case Reports

Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: evidence for a European sequence variant

Friederike D von Loewenich et al. J Clin Microbiol. 2010 Jul.

Abstract

Recently, a new genus of Anaplasmataceae termed "Candidatus Neoehrlichia" was discovered in ticks and rodents. Here, we report on two patients who suffered from febrile bacteremia due to "Candidatus Neoehrlichia mikurensis" associated with thrombotic or hemorrhagic events. 16S rRNA and groEL gene sequencing provided evidence of three groups of sequence variants.

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Figures

FIG. 1.
FIG. 1.
Phylogenetic tree of the 16S rRNA (A, B) and groEL (C, D) gene sequences inferred using the neighbor-joining method. Bootstrap values are shown next to the nodes of the trees. The scale bar indicates the number of base substitutions per site. The final data sets contained 1,293 and 968 positions, respectively. Following the sequence names are the respective GenBank accession numbers. The accession numbers of sequences newly reported in this study are in bold and underlined (tick W330 and patient 1; the sequence data for patient 2 are not depicted because they did not fulfill the minimum length requirements for phylogenetic comparison to other published sequence data). The condensed trees (B, D) were calculated by applying a cutoff value of 95%.
See this image and copyright information in PMC

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