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Page 1
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.
Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M, Post JM, Lopez-Román EM, Engelhart CA, Lukac I, Zuccotto F, Epemolu O, Boshoff HIM, Schnappinger D, Walpole C, Gilbert IH, Read KD, Wyatt PG, Baragaña B. Green SR, et al. Among authors: eadsforth tc. J Med Chem. 2023 Nov 23;66(22):15380-15408. doi: 10.1021/acs.jmedchem.3c01514. Epub 2023 Nov 10. J Med Chem. 2023. PMID: 37948640 Free PMC article.
Structure and mechanism of imidazoleglycerol-phosphate dehydratase.
Glynn SE, Baker PJ, Sedelnikova SE, Davies CL, Eadsforth TC, Levy CW, Rodgers HF, Blackburn GM, Hawkes TR, Viner R, Rice DW. Glynn SE, et al. Among authors: eadsforth tc. Structure. 2005 Dec;13(12):1809-17. doi: 10.1016/j.str.2005.08.012. Structure. 2005. PMID: 16338409 Free article.
Mechanistic Insights into Dual-Active Liver and Blood-Stage Antiplasmodials.
Rawat M, Boonyalai N, Smidt C, Luth MR, Chen D, Plater A, Post J, Lin D, McMillan J, Eadsforth T, Moliner-Cubel S, Billker O, Rayner JC, Gamo FJ, Baragaña B, Winzeler EA, Lee MCS. Rawat M, et al. Among authors: eadsforth t. bioRxiv [Preprint]. 2025 Aug 6:2025.08.06.666330. doi: 10.1101/2025.08.06.666330. bioRxiv. 2025. PMID: 40799604 Free PMC article. Preprint.
Two high-resolution structures of the human E3 ubiquitin ligase Siah1.
Rimsa V, Eadsforth TC, Hunter WN. Rimsa V, et al. Among authors: eadsforth tc. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1339-43. doi: 10.1107/S1744309113031448. Epub 2013 Nov 28. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013. PMID: 24316825 Free PMC article.
21 results