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Regression-based Deep-Learning predicts molecular biomarkers from pathology slides.
El Nahhas OSM, Loeffler CML, Carrero ZI, van Treeck M, Kolbinger FR, Hewitt KJ, Muti HS, Graziani M, Zeng Q, Calderaro J, Ortiz-Brüchle N, Yuan T, Hoffmeister M, Brenner H, Brobeil A, Reis-Filho JS, Kather JN. El Nahhas OSM, et al. Nat Commun. 2024 Feb 10;15(1):1253. doi: 10.1038/s41467-024-45589-1. Nat Commun. 2024. PMID: 38341402 Free PMC article.
Multimodal histopathologic models stratify hormone receptor-positive early breast cancer.
Boehm KM, El Nahhas OSM, Marra A, Waters M, Jee J, Braunstein L, Schultz N, Selenica P, Wen HY, Weigelt B, Paul ED, Cekan P, Erber R, Loeffler CML, Guerini-Rocco E, Fusco N, Frascarelli C, Mane E, Munzone E, Dellapasqua S, Zagami P, Curigliano G, Razavi P, Reis-Filho JS, Pareja F, Chandarlapaty S, Shah SP, Kather JN. Boehm KM, et al. Among authors: el nahhas osm. Nat Commun. 2025 Mar 2;16(1):2106. doi: 10.1038/s41467-025-57283-x. Nat Commun. 2025. PMID: 40025017 Free PMC article.
Prediction of homologous recombination deficiency from routine histology with attention-based multiple instance learning in nine different tumor types.
Loeffler CML, El Nahhas OSM, Muti HS, Carrero ZI, Seibel T, van Treeck M, Cifci D, Gustav M, Bretz K, Gaisa NT, Lehmann KV, Leary A, Selenica P, Reis-Filho JS, Ortiz-Bruechle N, Kather JN. Loeffler CML, et al. Among authors: el nahhas osm. BMC Biol. 2024 Oct 8;22(1):225. doi: 10.1186/s12915-024-02022-9. BMC Biol. 2024. PMID: 39379982 Free PMC article.
Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab-bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study.
Zeng Q, Klein C, Caruso S, Maille P, Allende DS, Mínguez B, Iavarone M, Ningarhari M, Casadei-Gardini A, Pedica F, Rimini M, Perbellini R, Boulagnon-Rombi C, Heurgué A, Maggioni M, Rela M, Vij M, Baulande S, Legoix P, Lameiras S; HCC-AI study group; Bruges L, Gnemmi V, Nault JC, Campani C, Rhee H, Park YN, Iñarrairaegui M, Garcia-Porrero G, Argemi J, Sangro B, D'Alessio A, Scheiner B, Pinato DJ, Pinter M, Paradis V, Beaufrère A, Peter S, Rimassa L, Di Tommaso L, Vogel A, Michalak S, Boursier J, Loménie N, Ziol M, Calderaro J. Zeng Q, et al. Lancet Oncol. 2023 Dec;24(12):1411-1422. doi: 10.1016/S1470-2045(23)00468-0. Epub 2023 Nov 8. Lancet Oncol. 2023. PMID: 37951222
Direct image to subtype prediction for brain tumors using deep learning.
Hewitt KJ, Löffler CML, Muti HS, Berghoff AS, Eisenlöffel C, van Treeck M, Carrero ZI, El Nahhas OSM, Veldhuizen GP, Weil S, Saldanha OL, Bejan L, Millner TO, Brandner S, Brückmann S, Kather JN. Hewitt KJ, et al. Among authors: el nahhas osm. Neurooncol Adv. 2023 Nov 1;5(1):vdad139. doi: 10.1093/noajnl/vdad139. eCollection 2023 Jan-Dec. Neurooncol Adv. 2023. PMID: 38106649 Free PMC article.
15 results