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Case Reports
. 2009 Apr;47(4):1244-8.
doi: 10.1128/JCM.02030-08. Epub 2009 Jan 26.

Mucor circinelloides as a cause of invasive maxillofacial zygomycosis: an emerging dimorphic pathogen with reduced susceptibility to posaconazole

Zia U Khan  1 , Suhail Ahmad, Arnost Brazda, Rachel Chandy
Affiliations
Case Reports

Mucor circinelloides as a cause of invasive maxillofacial zygomycosis: an emerging dimorphic pathogen with reduced susceptibility to posaconazole

Zia U Khan et al. J Clin Microbiol. 2009 Apr.

Abstract

A case of maxillofacial zygomycosis caused by Mucor circinelloides, identified by phenotypic and molecular methods and treated successfully with liposomal amphotericin B (AmBisome) and surgical debridement, is described. The isolate was resistant to posaconazole. This report underscores the importance of prior susceptibility testing of zygomycetes to guide therapy with the most effective antifungal agent for an improved prognosis.

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Figures

FIG. 1.
FIG. 1.
(A) Branched circinate sporangiophores, sporangia, and collumellae; (B) chlamydospores of M. circinelloides formed successively in chains. Magnification, ×400.
FIG. 2.
FIG. 2.
(A and B) Growth of M. circinelloides in BHI agar at 37°C, showing hyphae with arthroconidium formation and yeast forms with single, bipolar, and multipolar buds. Magnification, ×600.
See this image and copyright information in PMC

References

    1. Ahmad, S., Z. Khan, A. S. Mustafa, and Z. U. Khan. 2002. Seminested PCR for diagnosis of candidemia: comparison with culture, antigen detection, and biochemical methods for species identification. J. Clin. Microbiol. 402483-2489. - PMC - PubMed
    1. Ahmad, S., M. Al-Mahmeed, and Z. U. Khan. 2005. Characterization of Trichosporon species isolated from clinical specimens in Kuwait. J. Med. Microbiol. 54639-646. - PubMed
    1. Ahmad, S., Z. U. Khan, and A. M. Theyyathel. 2007. Value of Aspergillus terreus-specific DNA, (1-3)-β-D-glucan and galactomannan detection in serum and bronchoalveolar lavage specimens of experimentally infected mice. Diagn. Microbiol. Infect. Dis. 59165-171. - PubMed
    1. Almyroudis, N. G., D. A. Sutton, A. W. Fothergill, M. G. Rinaldi, and S. Kusne. 2007. In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. Antimicrob. Agents Chemother. 512587-2590. - PMC - PubMed
    1. Borman, A. M., C. J. Linton, S. J. Miles, and E. M. Johnson. 2008. Molecular identification of pathogenic fungi. J. Antimicrob. Chemother. 61(Suppl. 1)i7-i12. - PubMed

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