Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.
Thoma G, Miltz W, Waelchli R, Orain D, Spanka C, Decoret O, Wolf RM, Hurley B, Cheung AK, Sandham DA, Honda A, Tichkule R, Chen X, Patel T, Labbe-Giguere N, Tan KL, Springer C, Manchester J, Culshaw AJ, Hunt P, Srinivas H, Penno CA, Ferrand S, Numao S, Schopfer U, Jäger P, Wack N, Hasler F, Urban B, Sindelar M, Loetscher P, Kiffe M, Ren X, Nicklin P, White K, Subramanian K, Liu H, Growcott EJ, Röhn TA.
Thoma G, et al. Among authors: ferrand s.
J Med Chem. 2025 Feb 27;68(4):4721-4742. doi: 10.1021/acs.jmedchem.4c02897. Epub 2025 Feb 17.
J Med Chem. 2025.
PMID: 39960261