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Year Number of Results
2019 4
2020 24
2021 83
2022 182
2023 486
2024 1128
2025 833

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Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine.
Sun X, Chen B, Qi Y, Wei M, Chen W, Wu X, Wang Q, Li J, Lei X, Luo G. Sun X, et al. J Headache Pain. 2024 Jul 22;25(1):117. doi: 10.1186/s10194-024-01828-w. J Headache Pain. 2024. PMID: 39039470 Free PMC article.
METHOD: We used Mendelian Randomization (MR) and Summary-data-based MR (SMR) analyses to study possible drug targets of migraine by summary statistics from FinnGen cohorts (nCase = 44,616, nControl = 367,565), with further replication in UK Biobank (nCase = 26,052, nContro …
METHOD: We used Mendelian Randomization (MR) and Summary-data-based MR (SMR) analyses to study possible drug targets of migraine by summary …
Association between frailty and depression: A bidirectional Mendelian randomization study.
Deng MG, Liu F, Liang Y, Wang K, Nie JQ, Liu J. Deng MG, et al. Sci Adv. 2023 Sep 22;9(38):eadi3902. doi: 10.1126/sciadv.adi3902. Epub 2023 Sep 20. Sci Adv. 2023. PMID: 37729413 Free PMC article.
We obtained frailty genome-wide association study (GWAS) data from UK Biobank and TwinGen meta-analysis, and depression GWAS data from Psychiatric Genomics Consortium (PGC) and FinnGen (respectively recorded as PD and FD). We performed univariable and multivariable-adjuste …
We obtained frailty genome-wide association study (GWAS) data from UK Biobank and TwinGen meta-analysis, and depression GWAS data from Psych …
Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis.
Lin J, Zhou J, Xu Y. Lin J, et al. Brain. 2023 Aug 1;146(8):3364-3372. doi: 10.1093/brain/awad070. Brain. 2023. PMID: 36864689 Free PMC article.
We performed Mendelian randomization to explore potential drug targets for multiple sclerosis using summary statistics from the International Multiple Sclerosis Genetics Consortium (nCase = 47 429, nControl = 68 374) and further replicated in UK Biobank (nCase = 1356, nControl = …
We performed Mendelian randomization to explore potential drug targets for multiple sclerosis using summary statistics from the Internationa …
A FinnGen pilot clinical recall study for Alzheimer's disease.
Julkunen V, Schwarz C, Kalapudas J, Hallikainen M, Piironen AK, Mannermaa A, Kujala H, Laitinen T, Kosma VM, Paajanen TI, Kälviäinen R, Hiltunen M, Herukka SK, Kärkkäinen S, Kokkola T, Urjansson M; FinnGen; Perola M, Palotie A, Vuoksimaa E, Runz H. Julkunen V, et al. Sci Rep. 2023 Aug 3;13(1):12641. doi: 10.1038/s41598-023-39835-7. Sci Rep. 2023. PMID: 37537264 Free PMC article.
As a result, 19% (27/140) of a pre-specified FinnGen subcohort were successfully recalled and completed the study. Hospital records largely validated registry entries. ...We conclude that informative, customized clinical recall studies from FinnGen are feasible....
As a result, 19% (27/140) of a pre-specified FinnGen subcohort were successfully recalled and completed the study. Hospital records l …
Causal effect of thyroid cancer on secondary primary malignancies: findings from the UK Biobank and FinnGen cohorts.
Wang Z, Rixiati Y, Jia C, Xu Y, Yin Z, Huang J, Dai J, Zhang Y. Wang Z, et al. Front Immunol. 2024 Sep 26;15:1434737. doi: 10.3389/fimmu.2024.1434737. eCollection 2024. Front Immunol. 2024. PMID: 39391305 Free PMC article.
RESULTS: Summary datasets of genome-wide association studies (GWAS) on 30 types of cancers were obtained from the United Kingdom Biobank (UKB) and FinnGen database. Meta-analysis of the UKB and FinnGen results revealed that THCA was significantly positively correlat …
RESULTS: Summary datasets of genome-wide association studies (GWAS) on 30 types of cancers were obtained from the United Kingdom Biobank (UK …
Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F. Si S, et al. Front Immunol. 2021 Jul 27;12:720876. doi: 10.3389/fimmu.2021.720876. eCollection 2021. Front Immunol. 2021. PMID: 34386016 Free PMC article.
There were positive associations with impetigo, vascular dementia, bipolar disorders, hypercholesterolemia, vertigo, and neurological diseases, and negative correlations with degenerative macular diseases, metatarsalgia, interstitial lung disease, and idiopathic pulmonary fibrosi …
There were positive associations with impetigo, vascular dementia, bipolar disorders, hypercholesterolemia, vertigo, and neurological diseas …
Coffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study.
Yuan S, Larsson SC. Yuan S, et al. Am J Kidney Dis. 2022 Jan;79(1):9-14.e1. doi: 10.1053/j.ajkd.2021.04.018. Epub 2021 Oct 21. Am J Kidney Dis. 2022. PMID: 34690004 Free article.
Summary-level data for kidney stones were obtained from the UK Biobank study (6,536 cases and 388,508 noncases) and the FinnGen consortium (3,856 cases and 172,757 noncases). EXPOSURE: Genetically predicted coffee and caffeine consumption. ...RESULTS: Genetically predicted …
Summary-level data for kidney stones were obtained from the UK Biobank study (6,536 cases and 388,508 noncases) and the FinnGen conso …
Genome-wide association analysis of plasma lipidome identifies 495 genetic associations.
Ottensmann L, Tabassum R, Ruotsalainen SE, Gerl MJ, Klose C, Widén E; FinnGen; Simons K, Ripatti S, Pirinen M. Ottensmann L, et al. Nat Commun. 2023 Oct 31;14(1):6934. doi: 10.1038/s41467-023-42532-8. Nat Commun. 2023. PMID: 37907536 Free PMC article.
We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. ...
We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 g …
Smoking, alcohol and coffee consumption and pregnancy loss: a Mendelian randomization investigation.
Yuan S, Liu J, Larsson SC. Yuan S, et al. Fertil Steril. 2021 Oct;116(4):1061-1067. doi: 10.1016/j.fertnstert.2021.05.103. Epub 2021 Jun 27. Fertil Steril. 2021. PMID: 34187701 Free article.
DESIGN: Mendelian randomization study. SETTING: The UK Biobank study and FinnGen consortium. PATIENTS: A total of 60,565 cases with pregnancy loss and 130,687 noncases from UK Biobank and 3,312 cases with pregnancy loss and 64,578 noncases from FinnGen. ...RESULT(S) …
DESIGN: Mendelian randomization study. SETTING: The UK Biobank study and FinnGen consortium. PATIENTS: A total of 60,565 cases with p …
2,554 results