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Observational Study
. 2022 Dec 20;15(1):373.
doi: 10.1186/s13104-022-06264-0.

Real world data from a multi-centre study on the effects of cilostazol on pain symptoms and walking distance in patients with peripheral arterial disease

Niki Katsiki  1   2 , Nikolaos Tentolouris  3 , Georgios Marakomichelakis  4 , Dimitrios Richter  5 , Athanasios Giannoukas  6 , Panagiota Koufaki  7 , Nikolaos Papanas  8 ; CI-WIN Investigators
Collaborators, Affiliations
Observational Study

Real world data from a multi-centre study on the effects of cilostazol on pain symptoms and walking distance in patients with peripheral arterial disease

Niki Katsiki et al. BMC Res Notes. .

Abstract

Objective: to assess the effects of cilostazol on pain-free walking distance in PAD patients with IC at 3 and 6 months in a real world, prospective, observational study. We included 1015 PAD patients presenting with IC (71.3% men, 93.5% white, mean age 69.2 ± 8.7 years). Patients were followed up for 6 months by their physicians.

Results: Cilostazol significantly increased pain-free walking distance by a median of 285 and 387 m at 3 and 6 months, respectively (p < 0.01 for all comparisons). This effect was significant for patients 50-74 years (but not for those aged ≥ 75 years) and independent of smoking status, changes in physical activity, comorbidities and concomitant medication for PAD (i.e., acetylsalicylic acid and clopidogrel). Furthermore, significant reductions were observed in systolic (from 139 ± 16 to 133 ± 14 mmHg; p < 0.001) and diastolic blood pressure (from 84 ± 9 mmHg to 80 ± 10 mmHg; p < 0.001). Smoking cessation and increased physical activity were reported by the majority of participants. In conclusion, cilostazol was shown to safely decrease pain symptoms and improve pain-free walking in PAD patients with IC in a real world setting. Benefits also occurred in terms of BP and lifestyle changes.

Keywords: Cilostazol; Intermittent claudication; Pain-free walking distance; Peripheral arterial disease.

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Conflict of interest statement

NK has given talks, attended conferences and participated in trials sponsored by Angelini, Astra Zeneca, Bausch Health, Boehringer Ingelheim, Elpen, Mylan, Novo Nordisk, Sanofi and Servier. NP has been an advisory board member of Astra-Zeneca, Boehringer Ingelheim, MSD, Novo Nordisk, Pfizer, Takeda and TrigoCare International; has participated in sponsored studies by Astra-Zeneca, Eli-Lilly, GSK, MSD, Novo Nordisk, Novartis and Sanofi-Aventis; has received honoraria as a speaker for Astra-Zeneca, Boehringer Ingelheim, Eli-Lilly, ELPEN, Galenica, MSD, Mylan, Novo Nordisk, Pfizer, Sanofi-Aventis, Takeda and Vianex; and attended conferences sponsored by TrigoCare International, Eli-Lilly, Galenica, Novo Nordisk, Pfizer and Sanofi-Aventis. AG has given talks, attended conferences and participated in trials sponsored by Bayer and Servier. DR has been an advisory board member of Astra-Zeneca, Bayer, Boehringer Ingelheim, MSD, Novartis; has participated in sponsored studies by Amgen, Sanofi, MSD; has received honoraria as a speaker for Astra-Zeneca, Bayer, Amgen, Boehringer Ingelheim, Eli-Lilly, ELPEN, Recordati, Demo, MSD, Viatris, Medtronic, Winmedica, Servier, Edwards, Novo Nordisk, Pfizer, Sanofi-Aventis, Vianex. GK is an employee of WINMEDICA, HELLAS. ΝΤ reports consultation fees from MSD, Sanofi, Novo Nordisk, Swedish Orphan Biovitrum AB, clinical trial fees from AstraZeneca, Eli Lilly, Boehringer Ingelheim, Sanofi, and Novo Nordisk, and unrestricted grants from Eli Lilly, Boehringer Ingelheim, ELPEN, and TrigoCare.

References

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