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1968 1
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49 results

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Page 1
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
Lanman BA, Allen JR, Allen JG, Amegadzie AK, Ashton KS, Booker SK, Chen JJ, Chen N, Frohn MJ, Goodman G, Kopecky DJ, Liu L, Lopez P, Low JD, Ma V, Minatti AE, Nguyen TT, Nishimura N, Pickrell AJ, Reed AB, Shin Y, Siegmund AC, Tamayo NA, Tegley CM, Walton MC, Wang HL, Wurz RP, Xue M, Yang KC, Achanta P, Bartberger MD, Canon J, Hollis LS, McCarter JD, Mohr C, Rex K, Saiki AY, San Miguel T, Volak LP, Wang KH, Whittington DA, Zech SG, Lipford JR, Cee VJ. Lanman BA, et al. Among authors: frohn mj. J Med Chem. 2020 Jan 9;63(1):52-65. doi: 10.1021/acs.jmedchem.9b01180. Epub 2019 Dec 24. J Med Chem. 2020. PMID: 31820981
Discovery of AMG 193, an MTA-Cooperative PRMT5 Inhibitor for the Treatment of MTAP-Deleted Cancers.
Pettus LH, Bourbeau M, Tamayo NA, Amegadzie A, Beylkin D, Booker SK, Butler J, Frohn MJ, Kaller MR, Kohn T, Lanman BA, Li K, Liu Q, Ma V, Medina J, Minatti AE, Lopez P, Manoni F, Pickrell A, Weires N, Andersson J, Cowland S, Glad S, Sarvary I, Vestergaard M, Li W, Ghimire-Rijal S, Mardirossian N, Mukund S, Chen Q, Lo MC, Ngo R, Khetan J, Madoux F, Sanders C, Sharma P, Wang P, Bruenner B, McCloud S, Ponce M, Soto M, Wahlstrom J, Xie F, Yang Y, Liu S, Tan H, Policheni A, Caenepeel S, Slemmons KK, Belmontes B, Hughes P, Allen JR. Pettus LH, et al. Among authors: frohn mj. J Med Chem. 2025 Apr 10;68(7):6932-6954. doi: 10.1021/acs.jmedchem.4c03121. Epub 2025 Mar 27. J Med Chem. 2025. PMID: 40146197 Clinical Trial.
Identification of Structurally Novel KRASG12C Inhibitors through Covalent DNA-Encoded Library Screening.
Huang D, Manoni F, Sun Z, Liu R, Allen JR, Banerjee A, Cee VJ, Eshon J, Frohn MJ, Kaller MR, Lee H, Li C, Li X, Lopez P, Ma V, Medina JM, Mohr C, Mukhina OA, Pickrell AJ, Stellwagen J, Wu W, Zhang W, Zhu K, Dahal UP, Hu LA, Leavitt M, Li W, Li Y, Ma Y, Rex K, Saiki AY, Wang P, Sun Y, Dai D, Tamayo NA, Lanman BA. Huang D, et al. Among authors: frohn mj. J Med Chem. 2025 Feb 27;68(4):4801-4817. doi: 10.1021/acs.jmedchem.4c03071. Epub 2025 Feb 11. J Med Chem. 2025. PMID: 39930787 Free PMC article.
Impact of glycation on antibody clearance.
Yang J, Primack R, Frohn M, Wang W, Luan P, Retter MW, Flynn GC. Yang J, et al. Among authors: frohn m. AAPS J. 2015 Jan;17(1):237-44. doi: 10.1208/s12248-014-9694-4. Epub 2014 Nov 21. AAPS J. 2015. PMID: 25413724 Free PMC article.
Structure--activity relationship of melatonin analogues.
Frohn MA, Seaborn CJ, Johnson DW, Phillipou G, Seamark RF, Matthews CD. Frohn MA, et al. Life Sci. 1980 Dec 1;27(22):2043-6. doi: 10.1016/0024-3205(80)90482-8. Life Sci. 1980. PMID: 7207006 No abstract available.
The optimization of aminooxadiazoles as orally active inhibitors of Cdc7.
Harrington PE, Bourbeau MP, Fotsch C, Frohn M, Pickrell AJ, Reichelt A, Sham K, Siegmund AC, Bailis JM, Bush T, Escobar S, Hickman D, Heller S, Hsieh F, Orf JN, Rong M, San Miguel T, Tan H, Zalameda L, Allen JG. Harrington PE, et al. Among authors: frohn m. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6396-400. doi: 10.1016/j.bmcl.2013.09.055. Epub 2013 Sep 25. Bioorg Med Chem Lett. 2013. PMID: 24120542
Dual thick and thin filament linked regulation of stretch- and L-NAME-induced tone in young and senescent murine basilar artery.
Lubomirov LT, Schroeter MM, Hasse V, Frohn M, Metzler D, Bust M, Pryymachuk G, Hescheler J, Grisk O, Chalovich JM, Smyth NR, Pfitzer G, Papadopoulos S. Lubomirov LT, et al. Among authors: frohn m. Front Physiol. 2023 Mar 28;14:1099278. doi: 10.3389/fphys.2023.1099278. eCollection 2023. Front Physiol. 2023. PMID: 37057180 Free PMC article.
Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.
Rzasa RM, Frohn MJ, Andrews KL, Chmait S, Chen N, Clarine JG, Davis C, Eastwood HA, Horne DB, Hu E, Jones AD, Kaller MR, Kunz RK, Miller S, Monenschein H, Nguyen T, Pickrell AJ, Porter A, Reichelt A, Zhao X, Treanor JJS, Allen JR. Rzasa RM, et al. Among authors: frohn mj. Bioorg Med Chem. 2014 Dec 1;22(23):6570-6585. doi: 10.1016/j.bmc.2014.10.013. Bioorg Med Chem. 2014. PMID: 25456383
49 results