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. 1996 Aug 15;36(1):70-85.
doi: 10.1006/geno.1996.0427.

A transcription map of the major histocompatibility complex (MHC) class I region

J R Gruen  1 , S R Nalabolu, T W Chu, C Bowlus, W F Fan, V L Goei, H Wei, R Sivakamasundari, Y Liu, H X Xu, S Parimoo, G Nallur, R Ajioka, H Shukla, P Bray-Ward, J Pan, S M Weissman
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A transcription map of the major histocompatibility complex (MHC) class I region

J R Gruen et al. Genomics. .

Abstract

We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxyl-terminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.

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