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BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.
Nature. 2011 May 19;473(7347):384-8. doi: 10.1038/nature09883.
Nature. 2011.
PMID: 21593872
Free PMC article.
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.
Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, Rosen N.
Pratilas CA, et al.
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4519-24. doi: 10.1073/pnas.0900780106. Epub 2009 Feb 27.
Proc Natl Acad Sci U S A. 2009.
PMID: 19251651
Free PMC article.
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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner.
Joseph EW, Pratilas CA, Poulikakos PI, Tadi M, Wang W, Taylor BS, Halilovic E, Persaud Y, Xing F, Viale A, Tsai J, Chapman PB, Bollag G, Solit DB, Rosen N.
Joseph EW, et al.
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14903-8. doi: 10.1073/pnas.1008990107. Epub 2010 Jul 28.
Proc Natl Acad Sci U S A. 2010.
PMID: 20668238
Free PMC article.
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