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Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Muta Y, Linares JF, Martinez-Ordoñez A, Duran A, Cid-Diaz T, Kinoshita H, Zhang X, Han Q, Nakanishi Y, Nakanishi N, Cordes T, Arora GK, Ruiz-Martinez M, Reina-Campos M, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, García-Solano J, Conesa-Zamora P, Inghirami G, Metallo CM, Osborne TF, Diaz-Meco MT, Moscat J. Muta Y, et al. Nat Commun. 2023 Dec 13;14(1):8075. doi: 10.1038/s41467-023-43690-5. Nat Commun. 2023. PMID: 38092754 Free PMC article.
Enteric glia regulate Paneth cell secretion and intestinal microbial ecology.
Prochera A, Muppirala AN, Kuziel GA, Soualhi S, Shepherd A, Sun L, Issac B, Rosenberg HJ, Karim F, Perez K, Smith KH, Archibald TH, Rakoff-Nahoum S, Hagen SJ, Rao M. Prochera A, et al. Elife. 2025 Apr 14;13:RP97144. doi: 10.7554/eLife.97144. Elife. 2025. PMID: 40227232 Free PMC article.
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer.
Sacchetti A, Teeuwssen M, Verhagen M, Joosten R, Xu T, Stabile R, van der Steen B, Watson MM, Gusinac A, Kim WK, Ubink I, Van de Werken HJ, Fumagalli A, Paauwe M, Van Rheenen J, Sansom OJ, Kranenburg O, Fodde R. Sacchetti A, et al. Elife. 2021 May 26;10:e61461. doi: 10.7554/eLife.61461. Elife. 2021. PMID: 34036938 Free PMC article.