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Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells.
Punyawatthananukool S, Matsuura R, Wongchang T, Katsurada N, Tsuruyama T, Tajima M, Enomoto Y, Kitamura T, Kawashima M, Toi M, Yamanoi K, Hamanishi J, Hisamori S, Obama K, Charoensawan V, Thumkeo D, Narumiya S. Punyawatthananukool S, et al. Nat Commun. 2024 Nov 1;15(1):9464. doi: 10.1038/s41467-024-53706-3. Nat Commun. 2024. PMID: 39487111 Free PMC article.