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Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages.

Lopes N, Boucherit N, Santamaria JC, Provin N, Charaix J, Ferrier P, Giraud M, Irla M. Lopes N, et al. Elife. 2022 Feb 21;11:e69982. doi: 10.7554/eLife.69982. Elife. 2022. PMID: 35188458 Free PMC article.

Aire-dependent genes undergo Clp1-mediated 3'UTR shortening associated with higher transcript stability in the thymus.

Guyon C, Jmari N, Padonou F, Li YC, Ucar O, Fujikado N, Coulpier F, Blanchet C, Root DE, Giraud M. Guyon C, et al. Elife. 2020 Apr 29;9:e52985. doi: 10.7554/eLife.52985. Elife. 2020. PMID: 32338592 Free PMC article.

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance.

Chuprin A, Avin A, Goldfarb Y, Herzig Y, Levi B, Jacob A, Sela A, Katz S, Grossman M, Guyon C, Rathaus M, Cohen HY, Sagi I, Giraud M, McBurney MW, Husebye ES, Abramson J. Chuprin A, et al. Nat Immunol. 2015 Jul;16(7):737-45. doi: 10.1038/ni.3194. Epub 2015 May 25. Nat Immunol. 2015. PMID: 26006015

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