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CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia.
He L, Arnold C, Thoma J, Rohde C, Kholmatov M, Garg S, Hsiao CC, Viol L, Zhang K, Sun R, Schmidt C, Janssen M, MacRae T, Huber K, Thiede C, Hébert J, Sauvageau G, Spratte J, Fluhr H, Aust G, Müller-Tidow C, Niehrs C, Pereira G, Hamann J, Tanaka M, Zaugg JB, Pabst C. He L, et al. EMBO Mol Med. 2022 Apr 7;14(4):e14990. doi: 10.15252/emmm.202114990. Epub 2022 Mar 7. EMBO Mol Med. 2022. PMID: 35253392 Free PMC article.