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. 2009 Oct;25(10):1045-8.
doi: 10.1089/aid.2009.0127.

Geographic HIV type 1 subtype distribution in Rakai district, Uganda

Aleisha N Collinson-Streng  1 , Andrew D Redd, Nelson K Sewankambo, David Serwadda, Mona Rezapour, Susanna L Lamers, Ronald H Gray, Maria J Wawer, Thomas C Quinn, Oliver Laeyendecker
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Geographic HIV type 1 subtype distribution in Rakai district, Uganda

Aleisha N Collinson-Streng et al. AIDS Res Hum Retroviruses. 2009 Oct.

Abstract

To analyze HIV-1 subtype distribution, sequence analysis was performed on serum specimens obtained in 1994 from the Rakai Health Sciences community cohort in Uganda. Portions of gag-p24 and env-gp41 were sequenced and HIV subtype was determined for 773 subjects residing in 10 community clusters in rural Uganda. Subtypes A (17%) and D (70%) were the most common strains in the population. Subtype distribution varied by geographic region with significantly more subtype A in northern community clusters compared with southern clusters (21% vs. 8%, p < 0.001) and more subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design.

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Figures

FIG. 1.
FIG. 1.
Percent Subtype and Genetic Diversity of the Community Clusters Grouped by Geographic Region
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