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. 2010 May;16(5):847-9.
doi: 10.3201/eid1605.091006.

Dengue virus surveillance for early warning, Singapore

Kim Sung Lee  1 , Yee Ling Lai, Sharon Lo, Timothy Barkham, Pauline Aw, Peng Lim Ooi, Ji Choong Tai, Martin Hibberd, Patrik Johansson, Seow Poh Khoo, Lee Ching Ng
Affiliations

Dengue virus surveillance for early warning, Singapore

Kim Sung Lee et al. Emerg Infect Dis. 2010 May.

Abstract

In Singapore, after a major outbreak of dengue in 2005, another outbreak occurred in 2007. Laboratory-based surveillance detected a switch from dengue virus serotype 1 (DENV-1) to DENV-2. Phylogenetic analysis showed a clade replacement within DENV-2 cosmopolitan genotype, which accompanied the predominant serotype switch, and cocirculation of multiple genotypes of DENV-3.

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Figures

Figure 1
Figure 1
Trends of monthly dengue cases in Singapore, 2005–2008, showing a switch in predominant serotype from dengue virus serotype 1 (DENV-1) to DENV-2 in January 2007 and cocirculation of all 4 serotypes with general dominance of DENV-1 and DENV-2 and lesser circulation of DENV-3 and DENV-4. *From ≈10% of all dengue cases.
Figure 2
Figure 2
Maximum-likelihood tree showing the phylogenetic relationship of A) dengue virus serotype 2 (DENV-2) and B) DENV-3 from Singapore and global isolates based on the envelope protein gene. EHI, sequence data generated at Environmental Health Institute; new clade, isolates obtained in 2007 and later; old clade, isolates obtained before 2007. Numbers on branches represent bootstrap percentages; only those >80% are shown. Scale bars indicate substitutions per site.
See this image and copyright information in PMC

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