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267 results

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Page 1
Structures and activation mechanism of the Gabija anti-phage system.
Li J, Cheng R, Wang Z, Yuan W, Xiao J, Zhao X, Du X, Xia S, Wang L, Zhu B, Wang L. Li J, et al. Nature. 2024 May;629(8011):467-473. doi: 10.1038/s41586-024-07270-x. Epub 2024 Mar 12. Nature. 2024. PMID: 38471529
Gabija is a highly widespread prokaryotic defence system that consists of two components, GajA and GajB(8). GajA functions as a DNA endonuclease that is inactive in the presence of ATP(9). Here, to explore how the Gabija system is activated for anti-phage defence, w …
Gabija is a highly widespread prokaryotic defence system that consists of two components, GajA and GajB(8). GajA functions as …
Structural basis of Gabija anti-phage defence and viral immune evasion.
Antine SP, Johnson AG, Mooney SE, Leavitt A, Mayer ML, Yirmiya E, Amitai G, Sorek R, Kranzusch PJ. Antine SP, et al. Nature. 2024 Jan;625(7994):360-365. doi: 10.1038/s41586-023-06855-2. Epub 2023 Nov 22. Nature. 2024. PMID: 37992757 Free PMC article.
Here we use X-ray crystallography and cryo-electron microscopy (cryo-EM) to define how Gabija proteins assemble into a supramolecular complex of around 500 kDa that degrades phage DNA. Gabija protein A (GajA) is a DNA endonuclease that tetramerizes to form the core of the …
Here we use X-ray crystallography and cryo-electron microscopy (cryo-EM) to define how Gabija proteins assemble into a supramolecular comple …
Molecular basis of Gabija anti-phage supramolecular assemblies.
Yang XY, Shen Z, Xie J, Greenwald J, Marathe I, Lin Q, Xie WJ, Wysocki VH, Fu TM. Yang XY, et al. Nat Struct Mol Biol. 2024 Aug;31(8):1243-1250. doi: 10.1038/s41594-024-01283-w. Epub 2024 Apr 16. Nat Struct Mol Biol. 2024. PMID: 38627580 Free PMC article.
Here we present cryo-EM structures of Bacillus cereus GajA and GajAB complex, revealing tetrameric and octameric assemblies, respectively. In the center of the complex, GajA assembles into a tetramer, which recruits two sets of GajB dimer at opposite sides of the co …
Here we present cryo-EM structures of Bacillus cereus GajA and GajAB complex, revealing tetrameric and octameric assemblies, respecti …
Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense.
Cheng R, Huang F, Lu X, Yan Y, Yu B, Wang X, Zhu B. Cheng R, et al. Cell Host Microbe. 2023 Aug 9;31(8):1331-1344.e5. doi: 10.1016/j.chom.2023.06.014. Epub 2023 Jul 21. Cell Host Microbe. 2023. PMID: 37480847 Free article.
The Gabija complex is a prokaryotic antiviral system consisting of the GajA and GajB proteins. GajA was identified as a DNA nicking endonuclease but the functions of GajB and the complex remain unknown. ...The antiviral activity of GajA requires GajB, which s …
The Gabija complex is a prokaryotic antiviral system consisting of the GajA and GajB proteins. GajA was identified as a DNA ni …
Structural and functional investigation of GajB protein in Gabija anti-phage defense.
Oh H, Koo J, An SY, Hong SH, Suh JY, Bae E. Oh H, et al. Nucleic Acids Res. 2023 Nov 27;51(21):11941-11951. doi: 10.1093/nar/gkad951. Nucleic Acids Res. 2023. PMID: 37897358 Free PMC article.
Gabija is one of the most abundant prokaryotic antiviral systems and consists of two proteins, GajA and GajB. GajA has been characterized experimentally as a sequence-specific DNA endonuclease. ...We demonstrated that GajB interacts with GajA to form a hetero …
Gabija is one of the most abundant prokaryotic antiviral systems and consists of two proteins, GajA and GajB. GajA has been ch …
Standardization of Gaja Puta and Ardha Gaja Puta in the preparation of Vanga Bhasma.
Parmar DK, Patgiri BJ, Prajapati PK. Parmar DK, et al. Ayu. 2010 Oct;31(4):511-5. doi: 10.4103/0974-8520.82028. Ayu. 2010. PMID: 22048550 Free PMC article.
The Vanga Bhasma is an important one amongst the metallic Bhasmas. Mainly Gaja Puta, Ardhagaja Puta and Laghu Puta have been described for Marana of Vanga. The medicines, which are prepared from Gaja Puta, are said to be the best ones (Mahagunavidhayaka). ...In the …
The Vanga Bhasma is an important one amongst the metallic Bhasmas. Mainly Gaja Puta, Ardhagaja Puta and Laghu Puta have been describe …
A nucleotide-sensing endonuclease from the Gabija bacterial defense system.
Cheng R, Huang F, Wu H, Lu X, Yan Y, Yu B, Wang X, Zhu B. Cheng R, et al. Nucleic Acids Res. 2021 May 21;49(9):5216-5229. doi: 10.1093/nar/gkab277. Nucleic Acids Res. 2021. PMID: 33885789 Free PMC article.
Here, we report functional analyses of the GajA protein from the newly predicted Gabija system. The GajA protein is revealed as a sequence-specific DNA nicking endonuclease unique in that its activity is strictly regulated by nucleotide concentration. NTP and dNTP a …
Here, we report functional analyses of the GajA protein from the newly predicted Gabija system. The GajA protein is revealed a …
[Psoriasis--arthritis].
Gaja A, Vykydal M. Gaja A, et al. Acta Univ Palacki Olomuc Fac Med. 1985;111:267-70. Acta Univ Palacki Olomuc Fac Med. 1985. PMID: 2949504 German. No abstract available.
Assessment of cyclone risk and case study of Gaja cyclone using GIS techniques and machine learning algorithms in coastal zone of Tamil Nadu, India.
Thenmozhi M, Sujatha M, Kavitha M, Senthilraja S, Babu M, Priya V. Thenmozhi M, et al. Environ Res. 2024 Apr 1;246:118089. doi: 10.1016/j.envres.2023.118089. Epub 2023 Dec 30. Environ Res. 2024. PMID: 38160970
These models were instrumental in generating pre- and post-cyclone land use maps. The influence of Gaja cyclones effects shows decreasing of agriculture land from 34% to 30%, aquaculture increase 1%, barren land decrease from 8% to 6%, Built-up land decrease from 15% to 13 …
These models were instrumental in generating pre- and post-cyclone land use maps. The influence of Gaja cyclones effects shows decrea …
Trace element contamination in marine sediments along the southeast Indian shelf following Cyclone Gaja.
Gopal V, Krishnamurthy RR, Chakraborty P, Magesh NS, Jayaprakash M. Gopal V, et al. Mar Pollut Bull. 2019 Dec;149:110520. doi: 10.1016/j.marpolbul.2019.110520. Epub 2019 Aug 21. Mar Pollut Bull. 2019. PMID: 31445350
In this study, twenty seven surface sediments were collected off Pushpavanam, Nagapattinam coast, southeast coast of India for understanding the sedimentological and geochemical behaviour after the Cyclone Gaja. The sediment samples were analysed for texture, organic matte …
In this study, twenty seven surface sediments were collected off Pushpavanam, Nagapattinam coast, southeast coast of India for understanding …
267 results