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Efficacy and safety of intravenous nerinetide initiated by paramedics in the field for acute cerebral ischaemia within 3 h of symptom onset (FRONTIER): a phase 2, multicentre, randomised, double-blind, placebo-controlled study.
Christenson J, Hill MD, Swartz RH, Adams C, Benavente O, Casaubon LK, Cheskes S, Ganesh A, Garman JD, Harris C, Harris DR, Heard K, Jenneson S, Kohli Y, Leroux M, Mayor-Nunez D, Medvedev G, Mehdiratta M, Morrison LJ, Ospel JM, Pennington S, Perez Y, Selchen D, Stebner A, Tallon J, Tkach A, Verbeek PR, Tymianski M. Christenson J, et al. Among authors: garman jd. Lancet. 2025 Feb 15;405(10478):571-582. doi: 10.1016/S0140-6736(25)00193-X. Lancet. 2025. PMID: 39955120 Clinical Trial.
Safety and efficacy of nerinetide in patients with acute ischaemic stroke enrolled in the early window: a post-hoc meta-analysis of individual patient data from three randomised trials.
Tymianski M, Hill MD, Goyal M, Christenson J, Menon BK, Swartz RH, Adams C, Heard K, Kohli Y; ESCAPE-NA1, ESCAPE-NEXT, and FRONTIER Investigators. Tymianski M, et al. Lancet Neurol. 2025 Mar;24(3):208-217. doi: 10.1016/S1474-4422(24)00515-5. Epub 2025 Feb 13. Lancet Neurol. 2025. PMID: 39956129
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