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Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.
St George-Hyslop PH, Haines JL, Farrer LA, Polinsky R, Van Broeckhoven C, Goate A, McLachlan DR, Orr H, Bruni AC, Sorbi S, Rainero I, Foncin JF, Pollen D, Cantu JM, Tupler R, Voskresenskaya N, Mayeux R, Growden J, Fried VA, Myers RH, Nee L, Backhovens H, Martin JJ, Rossor M, Owen MJ, Mullan M, Percy ME, Karlinsky H, Rich S, Heston L, Montesi M, Mortilla M, Nacmias N, Gusella JF, Hardy JA; FAD Collaborative Study Group, et al. St George-Hyslop PH, et al. Nature. 1990 Sep 13;347(6289):194-7. doi: 10.1038/347194a0. Nature. 1990. PMID: 2395471
A new Italian pedigree with early-onset Alzheimer's disease.
Rainero I, Bergamini L, Bruni AC, Ferini-Strambi L, Foncin JF, Gei G, Macciardi F, Montesi MP, Pinessi L, Vaula G. Rainero I, et al. Among authors: gei g. J Geriatr Psychiatry Neurol. 1994 Jan-Mar;7(1):28-32. J Geriatr Psychiatry Neurol. 1994. PMID: 8192827