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Page 1
Integration of transcriptomics, proteomics and loss-of-function screening reveals WEE1 as a target for combination with dasatinib against proneural glioblastoma.
Alhalabi OT, Göttmann M, Gold MP, Schlue S, Hielscher T, Iskar M, Kessler T, Hai L, Lokumcu T, Cousins CC, Herold-Mende C, Heßling B, Horschitz S, Jabali A, Koch P, Baumgartner U, Day BW, Wick W, Sahm F, Krieg SM, Fraenkel E, Phillips E, Goidts V. Alhalabi OT, et al. Among authors: gottmann m. Cancer Lett. 2024 Nov 28;605:217265. doi: 10.1016/j.canlet.2024.217265. Epub 2024 Sep 25. Cancer Lett. 2024. PMID: 39332586 Free article.
Development of a chemical probe against NUDT15.
Zhang SM, Desroses M, Hagenkort A, Valerie NCK, Rehling D, Carter M, Wallner O, Koolmeister T, Throup A, Jemth AS, Almlöf I, Loseva O, Lundbäck T, Axelsson H, Regmi S, Sarno A, Krämer A, Pudelko L, Bräutigam L, Rasti A, Göttmann M, Wiita E, Kutzner J, Schaller T, Kalderén C, Cázares-Körner A, Page BDG, Krimpenfort R, Eshtad S, Altun M, Rudd SG, Knapp S, Scobie M, Homan EJ, Berglund UW, Stenmark P, Helleday T. Zhang SM, et al. Among authors: gottmann m. Nat Chem Biol. 2020 Oct;16(10):1120-1128. doi: 10.1038/s41589-020-0592-z. Epub 2020 Jul 20. Nat Chem Biol. 2020. PMID: 32690945 Free PMC article.
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Zhang SM, Rehling D, Jemth AS, Throup A, Landázuri N, Almlöf I, Göttmann M, Valerie NCK, Borhade SR, Wakchaure P, Page BDG, Desroses M, Homan EJ, Scobie M, Rudd SG, Berglund UW, Söderberg-Nauclér C, Stenmark P, Helleday T. Zhang SM, et al. Among authors: gottmann m. Cell Chem Biol. 2021 Dec 16;28(12):1693-1702.e6. doi: 10.1016/j.chembiol.2021.06.001. Epub 2021 Jun 29. Cell Chem Biol. 2021. PMID: 34192523 Free article.
Malformin C preferentially kills glioblastoma stem-like cells via concerted induction of proteotoxic stress and autophagic flux blockade.
Phillips E, van Enk S, Kildgaard S, Schlue S, Göttmann M, Jennings V, Bethke F, Müller G, Herold-Mende C, Pastor-Flores D, Schneider M, Helm D, Ostenfeld Larsen T, Goidts V. Phillips E, et al. Among authors: gottmann m. Mol Oncol. 2025 Mar;19(3):785-807. doi: 10.1002/1878-0261.13756. Epub 2024 Oct 27. Mol Oncol. 2025. PMID: 39462997 Free PMC article.
A novel patient stratification strategy to enhance the therapeutic efficacy of dasatinib in glioblastoma.
Alhalabi OT, Fletcher MNC, Hielscher T, Kessler T, Lokumcu T, Baumgartner U, Wittmann E, Schlue S, Göttmann M, Rahman S, Hai L, Hansen-Palmus L, Puccio L, Nakano I, Herold-Mende C, Day BW, Wick W, Sahm F, Phillips E, Goidts V. Alhalabi OT, et al. Among authors: gottmann m. Neuro Oncol. 2022 Jan 5;24(1):39-51. doi: 10.1093/neuonc/noab158. Neuro Oncol. 2022. PMID: 34232320 Free PMC article.
PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma.
Phillips E, Balss J, Bethke F, Pusch S, Christen S, Hielscher T, Schnölzer M, Fletcher MNC, Habel A, Tessmer C, Brenner LM, Göttmann M, Capper D, Herold-Mende C, von Deimling A, Fendt SM, Goidts V. Phillips E, et al. Among authors: gottmann m. Oncogenesis. 2022 Sep 17;11(1):57. doi: 10.1038/s41389-022-00433-3. Oncogenesis. 2022. PMID: 36115843 Free PMC article.