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34 results

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Page 1
Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer.
Simoneau A, Engel JL, Bandi M, Lazarides K, Liu S, Meier SR, Choi AH, Zhang H, Shen B, Martires L, Gotur D, Pham TV, Li F, Gu L, Gong S, Zhang M, Wilker E, Pan X, Whittington DA, Throner S, Maxwell JP, Chen Y, Yu Y, Huang A, Andersen JN, Feng T. Simoneau A, et al. Among authors: gotur d. Mol Cancer Ther. 2023 Feb 1;22(2):215-226. doi: 10.1158/1535-7163.MCT-22-0409. Mol Cancer Ther. 2023. PMID: 36228090 Free PMC article.
A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair.
Castro J, Daniels MH, Brennan D, Johnston B, Gotur D, Lee YT, Knockenhauer KE, Lu C, Wu J, Nayak S, Collins C, Bansal R, Buker SM, Case A, Liu J, Yao S, Sparling BA, Sickmier EA, Silver SJ, Blakemore SJ, Boriack-Sjodin PA, Duncan KW, Ribich S, Copeland RA. Castro J, et al. Among authors: gotur d. Cancer Res. 2025 Feb 17;85(4):758-776. doi: 10.1158/0008-5472.CAN-24-0397. Cancer Res. 2025. PMID: 39589774 Free PMC article.
Efficacy and Safety of Remdesivir in People With Impaired Kidney Function Hospitalized for COVID-19 Pneumonia: A Randomized Clinical Trial.
Sise ME, Santos JR, Goldman JD, Tuttle KR, Teixeira JP, Seibert AF, Koullias Y, Llewellyn J, Regan S, Zhao Y, Huang H, Hyland RH, Osinusi A, Winter H, Humeniuk R, Hulter HN, Gottlieb RL, Fusco DN, Birne R, Stancampiano FF, Libertin CR, Small CB, Plate M, McPhail MJ; REDPINE Investigators. Sise ME, et al. Clin Infect Dis. 2024 Nov 22;79(5):1172-1181. doi: 10.1093/cid/ciae333. Clin Infect Dis. 2024. PMID: 38913574 Free PMC article. Clinical Trial.
Respiratory physiological changes in pregnancy.
Ejikeme C, Nandakumar V, Gotur D. Ejikeme C, et al. Among authors: gotur d. Respir Med. 2025 Sep;246:108245. doi: 10.1016/j.rmed.2025.108245. Epub 2025 Jul 3. Respir Med. 2025. PMID: 40614834 Review.
Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.
Daniels MH, Castro J, Lee YT, Gotur D, Knockenhauer KE, Grigoriu S, Lockbaum GJ, Cheong JE, Lu C, Brennan D, Buker SM, Liu J, Yao S, Sparling BA, Sickmier EA, Ribich S, Blakemore SJ, Silver SJ, Boriack-Sjodin PA, Duncan KW, Copeland RA. Daniels MH, et al. Among authors: gotur d. J Med Chem. 2025 May 8;68(9):9537-9554. doi: 10.1021/acs.jmedchem.5c00252. Epub 2025 Apr 29. J Med Chem. 2025. PMID: 40298172 Free PMC article.
Post-acute COVID-19 outcomes including participant-reported long COVID: amubarvimab/romlusevimab versus placebo in the ACTIV-2 trial.
Evering TH, Moser C, Jilg N, Ritz J, Wohl DA, Li JZ, Margolis D, Javan AC, Eron JJ, Currier JS, Daar ES, Smith DM, Hughes MD, Chew KW; ACTIV-2/A5401 Study Team. Evering TH, et al. EClinicalMedicine. 2024 Aug 16;75:102787. doi: 10.1016/j.eclinm.2024.102787. eCollection 2024 Sep. EClinicalMedicine. 2024. PMID: 39252866 Free PMC article.
Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers.
Cottrell KM, Briggs KJ, Whittington DA, Jahic H, Ali JA, Davis CB, Gong S, Gotur D, Gu L, McCarren P, Tonini MR, Tsai A, Wilker EW, Yuan H, Zhang M, Zhang W, Huang A, Maxwell JP. Cottrell KM, et al. Among authors: gotur d. J Med Chem. 2024 Apr 25;67(8):6064-6080. doi: 10.1021/acs.jmedchem.4c00133. Epub 2024 Apr 10. J Med Chem. 2024. PMID: 38595098 Free PMC article.
Impact of Small-N Studies During a Pandemic.
Corsello DP, Gotur DB, Carroll CL, Masud FN, Simpson SQ. Corsello DP, et al. Among authors: gotur db. Chest. 2020 Oct;158(4):1338-1340. doi: 10.1016/j.chest.2020.05.581. Epub 2020 Jun 11. Chest. 2020. PMID: 32533956 Free PMC article. No abstract available.
Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor.
Throner S, Feng T, Andersen JN, Bandi M, Engel JL, Gong S, Gotur D, Gu L, Huang A, Lazarides K, Maxwell JP, McCarren P, McMillan BJ, Pham TV, Simoneau A, Tsai A, Whittington DA, Wilker E, Zhang M, Zhang W. Throner S, et al. Among authors: gotur d. Bioorg Med Chem Lett. 2025 Aug 15;124:130262. doi: 10.1016/j.bmcl.2025.130262. Epub 2025 Apr 30. Bioorg Med Chem Lett. 2025. PMID: 40315934
34 results