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Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial.
Couturaud F, Schmidt J, Sanchez O, Ballerie A, Sevestre MA, Meneveau N, Bertoletti L, Connault J, Benhamou Y, Constans J, Quemeneur T, Lapébie FX, Pernod G, Picart G, Elias A, Doutrelon C, Neveux C, Khider L, Roy PM, Zuily S, Falvo N, Lacroix P, Emmerich J, Mahé I, Boileau J, Yaici A, Le Jeune S, Stéphan D, Plissonneau-Duquene P, Ray V, des Déserts MD, Belhadj-Chaidi R, Lamia B, Gruel Y, Presles E, Girard P, Tromeur C, Moustafa F, Rothstein V, Lacut K, Melac S, Barillot S, Mismetti P, Laporte S, Mottier D, Meyer G, Leroyer C; RENOVE Investigators. Couturaud F, et al. Lancet. 2025 Mar 1;405(10480):725-735. doi: 10.1016/S0140-6736(24)02842-3. Lancet. 2025. PMID: 40023651 Free article. Clinical Trial.
[Post-traumatic necrotizing fasciitis].
Puymirat E, Garnier S, Parizano JF, Grand H, Guimard CR, Gauche B. Puymirat E, et al. Among authors: guimard cr. Ann Fr Anesth Reanim. 2007 Jan;26(1):81-4. doi: 10.1016/j.annfar.2006.08.012. Epub 2006 Nov 13. Ann Fr Anesth Reanim. 2007. PMID: 17095183 French.
Is severe hypocalcemia immediately life threatening?
Duval M, Bach-Ngohou K, Masson D, Guimard C, Le Conte P, Trewick D. Duval M, et al. Among authors: guimard c. Endocr Connect. 2018 Oct;7(10):1067-1074. doi: 10.1530/EC-18-0267. Endocr Connect. 2018. PMID: 30311756 Free PMC article.
Towards the Lowest Efficacious Dose: Results From a Multicenter Noninferiority Randomized Open-Label Controlled Trial Assessing Tocilizumab or Abatacept Injection Spacing in Rheumatoid Arthritis in Remission.
Kedra J, Dieudé P, Giboin C, Marotte H, Salliot C, Schaeverbeke T, Perdriger A, Soubrier M, Morel J, Constantin A, Dernis E, Royant V, Salmon JH, Pham T, Gottenberg JE, Pertuiset E, Dougados M, Devauchelle-Pensec V, Gaudin P, Cormier G, Goupille P, Mariette X, Berenbaum F, Alcaix D, Rouidi SA, Berthelot JM, Monnier A, Piroth C, Lioté F, Goëb V, Gaujoux-Viala C, Chary-Valckenaere I, Hajage D, Tubach F, Fautrel B; CRI‐IMIDIATE clinical research network. Kedra J, et al. Arthritis Rheumatol. 2024 Apr;76(4):541-552. doi: 10.1002/art.42752. Epub 2024 Jan 25. Arthritis Rheumatol. 2024. PMID: 37942714 Clinical Trial.
Minimalist Natural ORPphilin Macarangin B Delineates OSBP Biological Function.
Jézéquel G, Grimanelli Z, Guimard C, Bigay J, Haddad J, Bignon J, Apel C, Steinmetz V, Askenatzis L, Levaïque H, Pradelli C, Pham VC, Huong DTM, Litaudon M, Gautier R, El Kalamouni C, Antonny B, Desrat S, Mesmin B, Roussi F. Jézéquel G, et al. Among authors: guimard c. J Med Chem. 2025 Jan 9;68(1):196-211. doi: 10.1021/acs.jmedchem.4c01705. Epub 2024 Dec 20. J Med Chem. 2025. PMID: 39704626
Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein.
Jézéquel G, Rampal C, Guimard C, Kovacs D, Polidori J, Bigay J, Bignon J, Askenatzis L, Litaudon M, Pham VC, Huong DTM, Nguyen AL, Pruvost A, Virolle T, Mesmin B, Desrat S, Antonny B, Roussi F. Jézéquel G, et al. Among authors: guimard c. J Med Chem. 2023 Oct 26;66(20):14208-14220. doi: 10.1021/acs.jmedchem.3c01298. Epub 2023 Oct 5. J Med Chem. 2023. PMID: 37795600