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. 2011 Jun;77(12):4256-9.
doi: 10.1128/AEM.02795-10. Epub 2011 Apr 22.

First evidence of genotypes Ad3a16 and Ad3a18 in North America, obtained by genetic analysis of infectious human adenovirus from wastewaters of two urban communities in Canada

Sinisa Vidovic  1 , Mahmoud Aly, Cecily Flemming, Susan Springthorpe, Syed A Sattar
Affiliations

First evidence of genotypes Ad3a16 and Ad3a18 in North America, obtained by genetic analysis of infectious human adenovirus from wastewaters of two urban communities in Canada

Sinisa Vidovic et al. Appl Environ Microbiol. 2011 Jun.

Abstract

A 1-year study found seven infectious human adenovirus serotypes, including Ad3, Ad31, Ad46, Ad27, Ad22, Ad51, and clinical clone PB3, in wastewaters of two major cities in Canada. Comparative genomic analysis revealed the existence of the reportedly highly contagious Ad3a16/18 genotypes. This is the first report of Ad3a16/18 genotypes in North America.

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Figures

Fig. 1.
Fig. 1.
Phylogenetic analysis of the hexon nucleic acid sequences of infectious HAdV isolates from this study and a set of sequences downloaded from GenBank used as references for different serotypes. The reference sequences are indicated in bold and labeled with their GenBank accession number, strain name, and serotype designation. The phylogenetic tree was constructed using the neighbor-joining method. The bootstrap values were generated with 1,000 pseudoreplicates. Scale bar indicates number of substitutions per site.
Fig. 2.
Fig. 2.
Multiple alignment of loop 2 region of hexon protein, including the Ad3 isolates obtained in this study with a reference sequence of Ad3a16 and/or Ad3a18 genotypes. Three amino acid substitutions, unique for Ad3a16 and Ad3a18 genotypes, are highlighted at 417, 429, and 439 amino acid positions of hexon protein.
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