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Page 1
A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance.
Kane J, Li X, Kumar S, Button-Simons KA, Vendrely Brenneman KM, Dahlhoff H, Sievert MAC, Checkley LA, Shoue DA, Singh PP, Abatiyow BA, Haile MT, Nair S, Reyes A, Tripura R, Peto TJ, Lek D, Mukherjee A, Kappe SHI, Dhorda M, Nkhoma SC, Cheeseman IH, Vaughan AM, Anderson TJC, Ferdig MT. Kane J, et al. Among authors: haile mt. mBio. 2024 Jul 17;15(7):e0080524. doi: 10.1128/mbio.00805-24. Epub 2024 Jun 24. mBio. 2024. PMID: 38912775 Free PMC article.
Plasmodium falciparum quinine resistance is multifactorial and includes a role for the drug/metabolite transporters PfCRT and DMT1.
Kanai M, Mok S, Yeo T, Shears MJ, Jeon JH, Narwal SK, Ross LS, Haile MT, Tripathi AK, Mlambo G, Kim J, Gil-Iturbe E, Okombo J, Park H, Wiradiputri K, Ward KE, Rozenberg FD, Fairhurst KJ, Bloxham TS, Bridgford JL, Sheth TR, Lee MCS, Small-Saunders JL, Mancia F, Quick M, Uhlemann AC, Sinnis P, Fidock DA. Kanai M, et al. Among authors: haile mt. bioRxiv [Preprint]. 2025 Apr 11:2024.09.27.615529. doi: 10.1101/2024.09.27.615529. bioRxiv. 2025. PMID: 39386571 Free PMC article. Preprint.
Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1.
Amambua-Ngwa A, Button-Simons KA, Li X, Kumar S, Brenneman KV, Ferrari M, Checkley LA, Haile MT, Shoue DA, McDew-White M, Tindall SM, Reyes A, Delgado E, Dalhoff H, Larbalestier JK, Amato R, Pearson RD, Taylor AB, Nosten FH, D'Alessandro U, Kwiatkowski D, Cheeseman IH, Kappe SHI, Avery SV, Conway DJ, Vaughan AM, Ferdig MT, Anderson TJC. Amambua-Ngwa A, et al. Among authors: haile mt. Nat Microbiol. 2023 Jul;8(7):1213-1226. doi: 10.1038/s41564-023-01377-z. Epub 2023 May 11. Nat Microbiol. 2023. PMID: 37169919 Free PMC article.
A genetically engineered Plasmodium falciparum parasite vaccine provides protection from controlled human malaria infection.
Murphy SC, Vaughan AM, Kublin JG, Fishbauger M, Seilie AM, Cruz KP, Mankowski T, Firat M, Magee S, Betz W, Kain H, Camargo N, Haile MT, Armstrong J, Fritzen E, Hertoghs N, Kumar S, Sather DN, Pinder LF, Deye GA, Galbiati S, Geber C, Butts J, Jackson LA, Kappe SHI. Murphy SC, et al. Among authors: haile mt. Sci Transl Med. 2022 Aug 24;14(659):eabn9709. doi: 10.1126/scitranslmed.abn9709. Epub 2022 Aug 24. Sci Transl Med. 2022. PMID: 36001680 Free PMC article.
33 results