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Page 1
Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial.
Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, Arabi YM, Heels-Ansdell D, Thabane L, Lamarche D, Surette M, Zytaruk N, Mehta S, Dodek P, McIntyre L, English S, Rochwerg B, Karachi T, Henderson W, Wood G, Ovakim D, Herridge M, Granton J, Wilcox ME, Goffi A, Stelfox HT, Niven D, Muscedere J, Lamontagne F, D'Aragon F, St-Arnaud C, Ball I, Nagpal D, Girard M, Aslanian P, Charbonney E, Williamson D, Sligl W, Friedrich J, Adhikari NK, Marquis F, Archambault P, Khwaja K, Kristof A, Kutsogiannis J, Zarychanski R, Paunovic B, Reeve B, Lellouche F, Hosek P, Tsang J, Binnie A, Trop S, Loubani O, Hall R, Cirone R, Reynolds S, Lysecki P, Golan E, Cartin-Ceba R, Taylor R, Cook D; Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Investigators and the Canadian Critical Care Trials Group. Johnstone J, et al. JAMA. 2021 Sep 21;326(11):1024-1033. doi: 10.1001/jama.2021.13355. JAMA. 2021. PMID: 34546300 Free PMC article. Clinical Trial.
Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.
Lamontagne F, Masse MH, Menard J, Sprague S, Pinto R, Heyland DK, Cook DJ, Battista MC, Day AG, Guyatt GH, Kanji S, Parke R, McGuinness SP, Tirupakuzhi Vijayaraghavan BK, Annane D, Cohen D, Arabi YM, Bolduc B, Marinoff N, Rochwerg B, Millen T, Meade MO, Hand L, Watpool I, Porteous R, Young PJ, D'Aragon F, Belley-Cote EP, Carbonneau E, Clarke F, Maslove DM, Hunt M, Chassé M, Lebrasseur M, Lauzier F, Mehta S, Quiroz-Martinez H, Rewa OG, Charbonney E, Seely AJE, Kutsogiannis DJ, LeBlanc R, Mekontso-Dessap A, Mele TS, Turgeon AF, Wood G, Kohli SS, Shahin J, Twardowski P, Adhikari NKJ; LOVIT Investigators and the Canadian Critical Care Trials Group. Lamontagne F, et al. N Engl J Med. 2022 Jun 23;386(25):2387-2398. doi: 10.1056/NEJMoa2200644. Epub 2022 Jun 15. N Engl J Med. 2022. PMID: 35704292 Clinical Trial.
The authors reply.
Angriman F, Muttalib F, Lamontagne F, Adhikari NKJ; LOVIT Investigators. Angriman F, et al. Crit Care Med. 2023 Dec 1;51(12):e283-e284. doi: 10.1097/CCM.0000000000006054. Epub 2023 Nov 16. Crit Care Med. 2023. PMID: 37971352 No abstract available.
Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.
LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators; Adhikari NKJ, Hashmi M, Tirupakuzhi Vijayaraghavan BK, Haniffa R, Beane A, Webb SA, Angus DC, Gordon AC, Cook DJ, Guyatt GH, Berry LR, Lorenzi E, Mouncey PR, Au C, Pinto R, Ménard J, Sprague S, Masse MH, Huang DT, Heyland DK, Nichol AD, McArthur CJ, de Man A, Al-Beidh F, Annane D, Anstey M, Arabi YM, Battista MC, Berry S, Bhimani Z, Bonten MJM, Bradbury CA, Brant EB, Brunkhorst FM, Burrell A, Buxton M, Cecconi M, Cheng AC, Cohen D, Cove ME, Day AG, Derde LPG, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Goossens H, Green C, Higgins AM, Hills TE, Horvat C, Ichihara N, Jayakumar D, Kanji S, Khoso MN, Lawler PR, Lewis RJ, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McQuilten ZK, McVerry BJ, Murthy S, Parke RL, Parker JC, Reyes LF, Rowan KM, Saito H, Salahuddin N, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Tolppa T, Trapani T, Turgeon AF, Turner AM, Udy AA, van de Veerdonk FL, Zarychanski R, Lamontagne F. LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators, et al. JAMA. 2023 Nov 14;330(18):1745-1759. doi: 10.1001/jama.2023.21407. JAMA. 2023. PMID: 37877585 Free PMC article.
Diarrhea in Mechanically Ventilated Patients: A Nested Multicenter Substudy.
Dionne JC, Johnstone J, Heels-Ansdell D, Tahvildar Khazaneh P, Zytaruk N, Clarke F, Hand L, Millen T, Dechert W, Porteous R, Auld F, Hunt M, Campbell E, Bentall T, Campbell T, Smith O, Rose L, Arabi YM, Duan E, Wilcox ME, McIntyre L, Rochwerg B, Karachi T, Adhikari NK, Charbonney E, St-Arnaud C, Kristof A, Khwaja K, Marquis F, Zarychanski R, Golan E, Cook D; PROSPECT Research Coordinators Group, the PROSPECT Investigators and the Canadian Critical Care Trials Group. Dionne JC, et al. Crit Care Med. 2025 Jun 1;53(6):e1247-e1256. doi: 10.1097/CCM.0000000000006667. Epub 2025 Apr 3. Crit Care Med. 2025. PMID: 40459385 Clinical Trial.
Effect of inhaled anaesthetics on cognitive and psychiatric outcomes in critically ill adults: a systematic review and meta-analysis.
Cuninghame S, Jerath A, Gorsky K, Sivajohan A, Francoeur C, Withington D, Burry L, Cuthbertson BH, Orser BA, Martin C, Owen AM, Slessarev M; Sedating with Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects on Ventilatory Parameters and Survival study investigators. Cuninghame S, et al. Br J Anaesth. 2023 Aug;131(2):314-327. doi: 10.1016/j.bja.2023.05.004. Epub 2023 Jun 19. Br J Anaesth. 2023. PMID: 37344338 Free article.
Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial.
Rynne J, Mosavie M, Masse MH, Ménard J, Battista MC, Maslove DM, Del Sorbo L, St-Arnaud C, DAragon F, Fox-Robichaud A, Charbonney E, Adhikari NKJ, Lamontagne F, Shankar-Hari M; LOVIT Investigators, the Canadian Critical Care Trials Group. Rynne J, et al. Intensive Care Med. 2025 Jan;51(1):82-93. doi: 10.1007/s00134-024-07733-9. Epub 2025 Jan 7. Intensive Care Med. 2025. PMID: 39774855 Clinical Trial.
Targeting optimal blood pressure monitoring: what's next?
Denault AY, Brassard P, Jacquet-Lagrèze M, Halwagi AE. Denault AY, et al. Among authors: halwagi ae. J Thorac Dis. 2018 Sep;10(Suppl 26):S3281-S3285. doi: 10.21037/jtd.2018.08.115. J Thorac Dis. 2018. PMID: 30370138 Free PMC article. No abstract available.
Effect of Inhaled Volatile and IV Anesthetics on Biological Markers of Inflammation in Adult ICU and Thoracic Surgical Patients: A Systematic Review and Meta-Analysis.
Rouhani S, Gupta S, Raheel H, Gao AD, Hanley C, Cao X, Iansavitchene A, Cuthbertson BH, Slessarev M, Goligher EC, Leligdowicz A, Fraser DD, Orser BA, Jerath A; SAVE-ICU Investigators. Rouhani S, et al. Crit Care Explor. 2025 Jul 10;7(7):e1280. doi: 10.1097/CCE.0000000000001280. eCollection 2025 Jul 1. Crit Care Explor. 2025. PMID: 40637441 Free PMC article.
16 results