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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1898 1
1946 1
1947 1
1948 2
1949 1
1950 3
1951 1
1955 2
1956 1
1957 1
1961 1
1962 4
1963 4
1964 3
1965 4
1966 1
1967 4
1968 5
1969 3
1970 2
1971 1
1972 8
1973 7
1974 5
1975 5
1976 1
1977 2
1978 4
1979 1
1980 5
1981 5
1982 4
1983 7
1984 6
1985 9
1986 7
1987 10
1988 2
1989 11
1990 13
1991 6
1992 6
1993 17
1994 17
1995 10
1996 9
1997 8
1998 12
1999 10
2000 4
2001 10
2002 7
2003 6
2004 8
2005 7
2006 4
2007 11
2008 11
2009 14
2010 18
2011 21
2012 18
2013 9
2014 11
2015 22
2016 18
2017 15
2018 24
2019 19
2020 20
2021 23
2022 22
2023 14
2024 19
2025 18

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581 results

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Page 1
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Among authors: hartley rc. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
Mitochondria as a therapeutic target for common pathologies.
Murphy MP, Hartley RC. Murphy MP, et al. Among authors: hartley rc. Nat Rev Drug Discov. 2018 Dec;17(12):865-886. doi: 10.1038/nrd.2018.174. Epub 2018 Nov 5. Nat Rev Drug Discov. 2018. PMID: 30393373 Free article. Review.
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP. Chouchani ET, et al. Among authors: hartley rc. Nature. 2014 Nov 20;515(7527):431-435. doi: 10.1038/nature13909. Epub 2014 Nov 5. Nature. 2014. PMID: 25383517 Free PMC article.
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.
Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D. Barnes NM, et al. Among authors: hartley rm. Pharmacol Rev. 2021 Jan;73(1):310-520. doi: 10.1124/pr.118.015552. Pharmacol Rev. 2021. PMID: 33370241 Free PMC article. Review.
Mitochondrial pharmacology.
Smith RA, Hartley RC, Cochemé HM, Murphy MP. Smith RA, et al. Among authors: hartley rc. Trends Pharmacol Sci. 2012 Jun;33(6):341-52. doi: 10.1016/j.tips.2012.03.010. Epub 2012 Apr 18. Trends Pharmacol Sci. 2012. PMID: 22521106 Free article. Review.
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation.
Casey AM, Ryan DG, Prag HA, Chowdhury SR, Marques E, Turner K, Gruszczyk AV, Yang M, Wolf DM, Miljkovic JL, Valadares J, Chinnery PF, Hartley RC, Frezza C, Prudent J, Murphy MP. Casey AM, et al. Among authors: hartley rc. Nat Metab. 2025 Mar;7(3):493-507. doi: 10.1038/s42255-025-01224-x. Epub 2025 Feb 19. Nat Metab. 2025. PMID: 39972217 Free PMC article.
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.
Khadka P, Reitman ZJ, Lu S, Buchan G, Gionet G, Dubois F, Carvalho DM, Shih J, Zhang S, Greenwald NF, Zack T, Shapira O, Pelton K, Hartley R, Bear H, Georgis Y, Jarmale S, Melanson R, Bonanno K, Schoolcraft K, Miller PG, Condurat AL, Gonzalez EM, Qian K, Morin E, Langhnoja J, Lupien LE, Rendo V, Digiacomo J, Wang D, Zhou K, Kumbhani R, Guerra Garcia ME, Sinai CE, Becker S, Schneider R, Vogelzang J, Krug K, Goodale A, Abid T, Kalani Z, Piccioni F, Beroukhim R, Persky NS, Root DE, Carcaboso AM, Ebert BL, Fuller C, Babur O, Kieran MW, Jones C, Keshishian H, Ligon KL, Carr SA, Phoenix TN, Bandopadhayay P. Khadka P, et al. Among authors: hartley r. Nat Commun. 2022 Feb 1;13(1):604. doi: 10.1038/s41467-022-28198-8. Nat Commun. 2022. PMID: 35105861 Free PMC article.
581 results