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Page 1
Pharmacogenomics of GPCR Drug Targets.
Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM. Hauser AS, et al. Cell. 2018 Jan 11;172(1-2):41-54.e19. doi: 10.1016/j.cell.2017.11.033. Epub 2017 Dec 14. Cell. 2018. PMID: 29249361 Free PMC article.
GPCR drug discovery: new agents, targets and indications.
Lorente JS, Sokolov AV, Ferguson G, Schiöth HB, Hauser AS, Gloriam DE. Lorente JS, et al. Among authors: hauser as. Nat Rev Drug Discov. 2025 Jun;24(6):458-479. doi: 10.1038/s41573-025-01139-y. Epub 2025 Mar 3. Nat Rev Drug Discov. 2025. PMID: 40033110 Review.
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics.
Wright SC, Motso A, Koutsilieri S, Beusch CM, Sabatier P, Berghella A, Blondel-Tepaz É, Mangenot K, Pittarokoilis I, Sismanoglou DC, Le Gouill C, Olsen JV, Zubarev RA, Lambert NA, Hauser AS, Bouvier M, Lauschke VM. Wright SC, et al. Among authors: hauser as. Nat Commun. 2023 Oct 9;14(1):6243. doi: 10.1038/s41467-023-41893-4. Nat Commun. 2023. PMID: 37813859 Free PMC article.
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.
Avet C, Mancini A, Breton B, Le Gouill C, Hauser AS, Normand C, Kobayashi H, Gross F, Hogue M, Lukasheva V, St-Onge S, Carrier M, Héroux M, Morissette S, Fauman EB, Fortin JP, Schann S, Leroy X, Gloriam DE, Bouvier M. Avet C, et al. Among authors: hauser as. Elife. 2022 Mar 18;11:e74101. doi: 10.7554/eLife.74101. Elife. 2022. PMID: 35302493 Free PMC article.
The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
Jain MK, Gumpper RH, Slocum ST, Schmitz GP, Madsen JS, Tummino TA, Suomivuori CM, Huang XP, Shub L, DiBerto JF, Kim K, DeLeon C, Krumm BE, Fay JF, Keiser M, Hauser AS, Dror RO, Shoichet B, Gloriam DE, Nichols DE, Roth BL. Jain MK, et al. Among authors: hauser as. Neuron. 2025 Oct 1;113(19):3129-3142.e9. doi: 10.1016/j.neuron.2025.06.012. Epub 2025 Jul 18. Neuron. 2025. PMID: 40683247
G protein-coupled receptor (GPCR) pharmacogenomics.
Thompson MD, Reiner-Link D, Berghella A, Rana BK, Rovati GE, Capra V, Gorvin CM, Hauser AS. Thompson MD, et al. Among authors: hauser as. Crit Rev Clin Lab Sci. 2024 Dec;61(8):641-684. doi: 10.1080/10408363.2024.2358304. Epub 2024 Aug 9. Crit Rev Clin Lab Sci. 2024. PMID: 39119983 Free article. Review.
The G protein database, GproteinDb.
Pándy-Szekeres G, Esguerra M, Hauser AS, Caroli J, Munk C, Pilger S, Keserű GM, Kooistra AJ, Gloriam DE. Pándy-Szekeres G, et al. Among authors: hauser as. Nucleic Acids Res. 2022 Jan 7;50(D1):D518-D525. doi: 10.1093/nar/gkab852. Nucleic Acids Res. 2022. PMID: 34570219 Free PMC article.
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes.
Kizilkaya HS, Sørensen KV, Madsen JS, Lindquist P, Douros JD, Bork-Jensen J, Berghella A, Gerlach PA, Gasbjerg LS, Mokrosiński J, Mowery SA, Knerr PJ, Finan B, Campbell JE, D'Alessio DA, Perez-Tilve D, Faas F, Mathiasen S, Rungby J, Sørensen HT, Vaag A, Nielsen JS, Holm JC, Lauenborg J, Damm P, Pedersen O, Linneberg A, Hartmann B, Holst JJ, Hansen T, Wright SC, Lauschke VM, Grarup N, Hauser AS, Rosenkilde MM. Kizilkaya HS, et al. Among authors: hauser as. Nat Metab. 2024 Jul;6(7):1268-1281. doi: 10.1038/s42255-024-01061-4. Epub 2024 Jun 13. Nat Metab. 2024. PMID: 38871982 Free PMC article.
48 results