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209 results

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Page 1
Showing results for hair eb
Search for Hayir EB instead (1 results)
Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche.
Cohen JN, Gouirand V, Macon CE, Lowe MM, Boothby IC, Moreau JM, Gratz IK, Stoecklinger A, Weaver CT, Sharpe AH, Ricardo-Gonzalez RR, Rosenblum MD. Cohen JN, et al. Sci Immunol. 2024 Jan 5;9(91):eadh0152. doi: 10.1126/sciimmunol.adh0152. Epub 2024 Jan 5. Sci Immunol. 2024. PMID: 38181095 Free PMC article.
Selective depletion of skin T(regs) resulted in T cell-mediated inflammation of hair follicles (HFs). Suppression did not rely on CTLA-4, but instead on high-affinity interleukin-2 (IL-2) receptor expression by skin T(regs), functioning exclusively in a cell-extrinsic mann …
Selective depletion of skin T(regs) resulted in T cell-mediated inflammation of hair follicles (HFs). Suppression did not rely on CTL …
Wnt signaling modulates mechanotransduction in the epidermis to drive hair follicle regeneration.
Oak ASW, Bagchi A, Brukman MJ, Toth J, Ford J, Zheng Y, Nace A, Yang R, Hsieh JC, Hayden JE, Ruthel G, Ray A, Kim E, Shenoy VB, Cotsarelis G. Oak ASW, et al. Sci Adv. 2025 Feb 21;11(8):eadq0638. doi: 10.1126/sciadv.adq0638. Epub 2025 Feb 19. Sci Adv. 2025. PMID: 39970220 Free PMC article.
Most wounds form scars without hair follicles. However, in the wound-induced hair neogenesis (WIHN) model of skin regeneration, wounds regenerate hair follicles if tissue rigidity is optimal. ...
Most wounds form scars without hair follicles. However, in the wound-induced hair neogenesis (WIHN) model of skin regeneration …
Tissue engineering of human hair follicles using a biomimetic developmental approach.
Abaci HE, Coffman A, Doucet Y, Chen J, Jacków J, Wang E, Guo Z, Shin JU, Jahoda CA, Christiano AM. Abaci HE, et al. Nat Commun. 2018 Dec 13;9(1):5301. doi: 10.1038/s41467-018-07579-y. Nat Commun. 2018. PMID: 30546011 Free PMC article.
Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug screening for skin diseases; however, the incorporation of engineered skin appendages, such as hair follicles (HFs) …
Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable hu …
RONIN/HCF1-TFEB Axis Protects Against D-Galactose-Induced Cochlear Hair Cell Senescence Through Autophagy Activation.
Wei Y, Zhang Y, Cao W, Cheng N, Xiao Y, Zhu Y, Xu Y, Zhang L, Guo L, Song J, Sha SH, Shao B, Ma F, Yang J, Ying Z, He Z, Chai R, Fang Q, Yang J. Wei Y, et al. Adv Sci (Weinh). 2025 Aug;12(29):e2407880. doi: 10.1002/advs.202407880. Epub 2025 Feb 22. Adv Sci (Weinh). 2025. PMID: 39985193 Free PMC article.
Age-related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy. Despite the improved understanding of these processes, detailed molecular mechanisms underlying cochlear HC senescence remain unclear. Transcription Factor EB (T …
Age-related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy. Despite the improved underst …
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.
Griffin DR, Archang MM, Kuan CH, Weaver WM, Weinstein JS, Feng AC, Ruccia A, Sideris E, Ragkousis V, Koh J, Plikus MV, Di Carlo D, Segura T, Scumpia PO. Griffin DR, et al. Nat Mater. 2021 Apr;20(4):560-569. doi: 10.1038/s41563-020-00844-w. Epub 2020 Nov 9. Nat Mater. 2021. PMID: 33168979 Free PMC article.
Unexpectedly, despite showing the predicted slower enzymatic degradation in vitro, D-peptide crosslinked MAP hydrogel (D-MAP) hastened material degradation in vivo and imparted significant tissue regeneration to healed cutaneous wounds, including increased tensile strength and …
Unexpectedly, despite showing the predicted slower enzymatic degradation in vitro, D-peptide crosslinked MAP hydrogel (D-MAP) hastened mater …
Hair cell-specific Myo15 promoter-mediated gene therapy rescues hearing in DFNB9 mouse model.
Wang H, Xun M, Tang H, Zhao J, Hu S, Zhang L, Lv J, Wang D, Chen Y, Liu J, Li GL, Wang W, Shu Y, Li H. Wang H, et al. Mol Ther Nucleic Acids. 2024 Feb 2;35(1):102135. doi: 10.1016/j.omtn.2024.102135. eCollection 2024 Mar 12. Mol Ther Nucleic Acids. 2024. PMID: 38404504 Free PMC article.
In this study, we evaluated the expression efficiency and specificity of transgene delivered by AAV-PHP.eB under the inner ear sensory cell-specific Myo15 promoter. Compared with the ubiquitous CAG promoter, the Myo15 promoter initiates efficient expression of the GFP fluo …
In this study, we evaluated the expression efficiency and specificity of transgene delivered by AAV-PHP.eB under the inner ear sensor …
Endolymphatic hydrops and cochlear synaptopathy after noise exposure are distinct sequelae of hair cell stereociliary bundle trauma.
Fong ML, Paik CB, Quiñones PM, Walker CB, Serafino MJ, Pan DW, Martinez E, Wang J, Phillips GW, Applegate BE, Gratton MA, Oghalai JS. Fong ML, et al. Sci Rep. 2024 Oct 27;14(1):25660. doi: 10.1038/s41598-024-77154-7. Sci Rep. 2024. PMID: 39465341 Free PMC article.
In vivo cochlear imaging after blast exposure revealed dynamic increases in endolymph that involved hair cell mechanoelectrical transduction channel block but not the synaptic release of glutamate at the hair cell-auditory nerve synapse. ...They are simply co-existe …
In vivo cochlear imaging after blast exposure revealed dynamic increases in endolymph that involved hair cell mechanoelectrical trans …
Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear.
Hu SW, Lv J, Wang Z, Tang H, Wang H, Wang F, Wang D, Zhang J, Zhang L, Cao Q, Chen Y, Gao Z, Han Y, Wang W, Li GL, Shu Y, Li H. Hu SW, et al. Research (Wash D C). 2024 Apr 25;7:0341. doi: 10.34133/research.0341. eCollection 2024. Research (Wash D C). 2024. PMID: 38665848 Free PMC article.
Through this strategy, we truncated a native promoter for Myo15 expression in hair cells (HCs) in the inner ear, from 1,611 bp down to 1,157 bp, and further down to 956 bp. Under the control of these 2 promoters, green fluorescent protein packaged in AAV-PHP.eB was …
Through this strategy, we truncated a native promoter for Myo15 expression in hair cells (HCs) in the inner ear, from 1,611 bp down t …
Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing.
Zheng Z, Li G, Cui C, Wang F, Wang X, Xu Z, Guo H, Chen Y, Tang H, Wang D, Huang M, Chen ZY, Huang X, Li H, Li GL, Hu X, Shu Y. Zheng Z, et al. Signal Transduct Target Ther. 2022 Mar 14;7(1):79. doi: 10.1038/s41392-022-00893-4. Signal Transduct Target Ther. 2022. PMID: 35283480 Free PMC article.
We then injected a newly developed AAV vector (AAV-PHP.eB) based CasRx into the inner ears of neonatal Bth mice, and we found that Tmc1(Bth) was reduced by 70.2% in 2 weeks with few off-target effects in the whole transcriptome. Consistently, we found improved hair …
We then injected a newly developed AAV vector (AAV-PHP.eB) based CasRx into the inner ears of neonatal Bth mice, and we found that Tm …
209 results